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Table 5 Percentage of sequence families where DIALIGN-T is outperformed on IRMBASE 1.0 by alternative methods according to the sum-of-pairs score. The symbol + denotes statistically significant superiority, - statistically significant inferiority and 0 non-significant superiority or inferiority of DIALIGN-T, respectively. Significance has been calculated according to the Wilcoxon Matched Pairs Signed Rank Test with p ≤ 0.05).

From: DIALIGN-T: An improved algorithm for segment-based multiple sequence alignment

Method

ref1

ref2

ref3

Total

DIALIGN 2.2

20.00%+

23.33%0

23.33%+

22.22%+

T-COFFEE 1.37

40.00%0

31.67%+

41.67%+

37.78%+

PROBCONS 1.09

20.00%+

15.00%+

21.67%+

18.89%+

POA V2

16.67%+

0.00%+

0.00%+

5.55%+

MUSCLE 3.5

5.00%+

5.00%+

0.00%+

3.33%+

CLUSTAL W 1.83

0.00%+

0.00%0

0.00%0

0.0%+