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Table 9 Average running time (in seconds) per multiple alignment for the 180 sequence families of IRMBASE and for 141 sequence families in BAliBASE 2.1. Program runs were performed on a Linux workstation (RedHat 8.0) with an 3.2 GHz Pentium 4 processor and 2 GB Ram.

From: DIALIGN-T: An improved algorithm for segment-based multiple sequence alignment

Method Average runtime on IRMBASE 1.0 Average runtime on BAliBASE 2.1
DIALIGN-T 2.36 1.38
DIALIGN 2.2 3.33 1.30
T-COFFEE 1.37 27.54 7.64
PROBCONS 1.09 12.37 2.66
POA V2 1.44 0.58
MUSCLE 3.5 9.37 0.60
CLUSTAL W 1.83 1.41 0.47