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Table 1 Comparison of different databases, which could be used to annotate and analyze large-scale biological data. Simplified joins refers to the availability of a central key and the ability to join tables through simple queries. Remote access column refers only to a machine access to a database server.

From: GeneKeyDB: A lightweight, gene-centric, relational database to support data mining environments

Database

SQL

Web interface

Simplified joins

1Remote access

Automatic updates provided

Type

Structure available as

Modular design

Download

GeneKeyDB

Yes

2Indirect

Yes

No

Yes

Oracle

Oracle, mysql, postgresql

Yes

Yes

LocusLink (Entrez Gene)

No

Yes

Na

Na

No

Flat file(s)

Flat file only

Na

Yes

RefSeq

No

Yes

Na

Na

No

Flat file

Flat file only

Na

Yes

Ensembl (core databases)

Yes

Yes

No

Yes

No

Mysql

Mysql

No

Yes

EnsMART

Yes

Yes

Yes

Yes

No

Mysql

Mysql

No

Yes

Dragon

Yes

Yes

No

No

No

Mysql

Flat file only

No

Data files only

HomoloGene

No

Yes

Na

Na

No

Flat files, XML

XML

No

Yes

  1. 1Refers only to machine access to the relational databases.
  2. 2GeneKeyDB serves as a data mining environment to different tools, therefore these tools are could also be considered a part of the interface layer.