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Table 3 The number of enzymes for selected metabolic pathways from KEGG.

From: Columba: an integrated database of proteins, structures, and annotations

Metabolic pathway Enzyme total CATH class
  Total with str. coverage a / b a b Few
all pathways 1 952 508 26,0 443 114 107 15
Fatty acid biosynthesis (path 1) 14 7 50,0 6 0 2 0
Oxidative phosphorylation 10 5 50,0 3 3 3 1
Streptomycin biosynthesis 14 7 50,0 6 0 1 0
Pyrimidine metabolism 59 30 50,8 29 6 5 0
Selenoamino acid metabolism 21 11 52,3 11 2 2 1
Pentose phosphate pathway 33 18 54,5 17 2 2 2
Methionine metabolism 23 13 56,5 13 3 1 1
One carbon pool by folate 23 13 56,5 13 2 1 0
Phe, Tyr and Trp biosynthesis 31 19 61,2 18 6 2 0
Glycolysis / Gluconeogenesis 38 24 63,1 24 2 5 2
Reductive carboxylate cycle (CO2 fixation) 13 9 69,2 8 3 1 1
Aminoacyl-tRNA biosynthesis 21 16 76,1 16 8 6 0
Carbon fixation 23 18 78,2 18 2 3 0
  1. The sum of observations in CATH classes can be higher than the number of enzymes with structures from the pathway, because in one chain, several domains with distinct folds can occur.