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Table 2 Statistically significant SNP types relevant to esophageal squamous cell carcinoma. In 2000 runs of 10-fold cross-validation, 14 SNP types are found to be the esophageal squamous cell carcinoma relevant. They had frequencies greater than the critical value of 0.0095 at the 5% level of significance (P < 0.05). By applying these SNP types to the SNP data set, the first five SNP types have 95% confidence intervals (CIs) whose upper and lower limits not cross with OR = 1.

From: Decision Forest Analysis of 61 Single Nucleotide Polymorphisms in a Case-Control Study of Esophageal Cancer; a novel method

No

OR

95% CI

SNP site

   

Gene

RS number

Genotype

1

1.66

1.16 – 2.37

GADD45B

E1122

Homozygous common

2

1.50

1.05 – 2.15

ercc5_55

 

Homozygous common

3

1.44

1.00 – 2.06

COMT

rs4818

Homozygous common

4

0.55

0.38 – 0.79

GADD45B

E1122

Heterozygous

5

0.45

0.23 – 0.87

NQO1

rs1800566

Homozygous variant

6

1.64

0.70 – 3.87

ERCC5

rs17655

Homozygous variant

7

1.57

0.76 – 3.26

GPX1

rs1800668

Homozygous variant

8

1.43

0.98 – 2.09

NQO1

rs1800566

Heterozygous

9

1.05

0.73 – 1.52

ERCC2

rs1052559

Heterozygous

10

1.00

0.51 – 1.97

GADD45B

rs14384

Homozygous variant

11

0.99

0.51 – 1.91

CYP1A1

rs1048943

Homozygous variant

12

0.87

0.60 – 1.26

cyp1a2_5

 

Heterozygous

13

0.83

0.57 – 1.20

CYP1A2

rs2472304

Heterozygous

14

0.59

0.27 – 1.32

adh1b_55

 

Heterozygous