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Table 4 Statistically significant 2-SNP patterns relevant to esophageal squamous cell carcinoma. In 2000 runs of 10-fold cross-validation, 52 2-SNP patterns were found to be esophageal cancer relevant. They had frequencies greater than the critical value of 0.00024 at the 5% level of significance (P < 0.05). By applying these 2-SNP patterns to the SNP data set, 15 2-SNP patterns have 95% confidence intervals (CIs) whose upper and lower limits not cross with OR = 1.

From: Decision Forest Analysis of 61 Single Nucleotide Polymorphisms in a Case-Control Study of Esophageal Cancer; a novel method

No OR 95% CI SNP site 1 SNP site 2
    Gene RS number Genotype Gene RS number Genotype
1 2.33 1.29 – 4.19 NQO1 rs1800566 Heterozygous GADD45B E1122 Homozygous common
2 2.09 1.41 – 3.09 GADD45B E1122 Homozygous common COMT rs4818 Homozygous common
3 2.03 1.37 – 3.00 ercc5_55   Homozygous common GADD45B E1122 Homozygous common
4 0.61 0.38 – 0.98 cyp1a2_5   Heterozygous GADD45B E1122 Heterozygous
5 0.60 0.39 – 0.94 GADD45B E1122 Heterozygous ERCC2 rs1799787 Heterozygous
6 0.60 0.38 – 0.94 GADD45B E1122 Heterozygous COMT rs4818 Heterozygous
7 0.58 0.37 – 0.92 GADD45B E1122 Heterozygous CYP1A2 rs2472304 Heterozygous
8 0.58 0.37 – 0.89 GSTM3 rs1537234 Heterozygous GADD45B E1122 Heterozygous
9 0.57 0.36 – 0.90 GADD45B E1122 Heterozygous COMT rs4818 Homozygous common
10 0.57 0.37 – 0.87 LIG1 rs20579 Heterozygous GADD45B E1122 Heterozygous
11 0.54 0.35 – 0.84 GADD45B E1122 Heterozygous ERCC2 rs1052559 Homozygous common
12 0.45 0.28 – 0.72 GADD45B rs14384 Homozygous common GADD45B E1122 Heterozygous
13 0.40 0.26 – 0.63 GADD45B E1122 Heterozygous ERCC5 rs17655 Homozygous common
14 0.22 0.06 – 0.73 adh1b_55   Homozygous variant GADD45B E1122 Heterozygous
15 0.16 0.04 – 0.62 NQO1 rs1800566 Homozygous variant GADD45B E1122 Homozygous common