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Figure 6 | BMC Bioinformatics

Figure 6

From: Quality control and quality assessment of data from surface-enhanced laser desorption/ionization (SELDI) time-of flight (TOF) mass spectrometry (MS)

Figure 6

Examples of high and low quality spectra from technical replicates in myeloma-associated lytic bone disease study. The parallel coordinate plots of spectra of four replicates from sera of patients X and Y illustrate the difference between the high quality spectra and low quality spectra. Each peak in the spectra of four replicates were drawn as four points and linked together by a line to show the relative trend. The y-axis is the intensity. (A) Four spectra from replicates of serum of patient X showed very similar profiles and have a high degree of correlation to each other. (B) Spectra 1, 2, and 4 from patient Y have similar profiles and therefore have high correlations to each other. But spectrum 3 has a different profile from the others. Since it is not consistent with the other replicates, it should be discarded prior to data analysis.

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