Figure 1

HomoMINT as a web tool. HomoMINT can be searched and analyzed by taking advantage of the tools developed for MINT. A) A search can be carried out in the protein table by entering in the form one of the following: a protein name, a Uniprot or a PDB identifier, a keyword, an InterPro domain or a gene ontology term (top part of the form). Alternatively the search can be carried out on the interaction table (centre). Finally (lower part) a BLAST search can be carried out by entering a protein sequence. B) Search output listing on the right the partners of the query protein and on the left the experimental evidence supporting the interactions. C) The Mint Viewer is an applet that permits the graphic display of interaction networks. Edges marked by small blue circles indicate that the corresponding interactions were inferred from experiments carried out in model organisms, while yellow circles mark interactions supported by direct experimental results. Interactions that are inferred from model organisms but are also supported by direct experiments are marked by yellow circles with a blue contour. A series of check boxes make it possible to visualize interactions inferred by any combination of model organism interactomes.