Figure 3A

Stability normalization of Jaccard index. Illustration of stability normalization for the Jaccard index of a particular k-means clustering (k = 12), obtained on MAS- and RMA-pre-processed versions of the AML dataset (correlation distance, 3000 probesets). The dotted line corresponds to the Jaccard index between these clusterings (0.55). For both MAS and RMA, the CDF can be used to arrive at a stability normalized Jaccard index; in this case 0.90 and 0.16. The arrows indicate the Jaccard indices for which the normalised Jaccard index J^SN = 0.5. The interpretation is that for MAS, the comparison to RMA falls well within what can be expected, for RMA less so.