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Table 2 Coupling of prominent metabolites. The number of metabolites that couple with each compound. In the E. coli metabolic network, the proton participates in at least one reaction with 479 other unique metabolites. The ordering of metabolites is based on the number of reactions they participate in individually, averaged across all networks. Thus, the number of unique metabolites that couple with a given metabolite do not strictly have to decrease down a column, although it usually does.

From: Metabolite coupling in genome-scale metabolic networks

  Number of unique metabolites with which each prominent metabolite couples
Metabolite E. coli S. cerevisiae H. pylori S. aureus mitochondrion M. barkeri
H+ 479 490 291 400 97 402
H2O 368 361 214 275 65 265
ATP 220 262 135 214 59 215
ADP 179 161 114 142 42 134
Pi 184 161 123 132 34 165
PPi 140 175 101 143 28 166
CO2 116 125 90 122 33 104
NAD+ 126 121 44 108 34 86
NADP+ 92 144 71 97 14 86
NADH 123 116 37 111 34 78
CoA 72 109 46 95 49 59
NADPH 90 143 68 105 14 83
AMP 72 126 39 80 24 108
glu 84 80 57 71 17 91
NH4 80 88 58 68 14 64