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Table 3 Preferentially coupled metabolite pairs in E. coli. The preferentially coupled metabolite pairs in the E. coli metabolic network, computed as described in the text. All of these pairs occur more often in the real network then in any of 10,000 randomizations, for an effective p value of 0.

From: Metabolite coupling in genome-scale metabolic networks

H+ ATP
H+ ADP
H+ Nicotinamide adenine dinucleotide
H+ Nicotinamide adenine dinucleotide – reduced
H+ CO2
H+ Nicotinamide adenine dinucleotide phosphate
H+ Nicotinamide adenine dinucleotide phosphate – reduced
H2O Phosphate
H2O Ammonium
ATP Phosphate
ATP ADP
ATP Diphosphate
ATP AMP
Phosphate ADP
Nicotinamide adenine dinucleotide Nicotinamide adenine dinucleotide – reduced
Diphosphate AMP
Diphosphate 5-Phospho-alpha-D-ribose 1-diphosphate
Diphosphate Farnesyl diphosphate
CO2 Malonyl-[acyl-carrier protein]
CO2 Acetoacetyl-ACP
Nicotinamide adenine dinucleotide phosphate Nicotinamide adenine dinucleotide phosphate – reduced
Nicotinamide adenine dinucleotide phosphate Malonyl-[acyl-carrier protein]
Nicotinamide adenine dinucleotide phosphate Acetoacetyl-ACP
Pyruvate Phosphoenolpyruvate
Nicotinamide adenine dinucleotide phosphate – reduced Malonyl-[acyl-carrier protein]
Nicotinamide adenine dinucleotide phosphate – reduced Acetoacetyl-ACP
L-Glutamate 2-Oxoglutarate
L-Glutamate L-Glutamine
Coenzyme A Acetyl-CoA
Coenzyme A Succinyl-CoA
acyl carrier protein Malonyl-[acyl-carrier protein]
acyl carrier protein Acetoacetyl-ACP
acyl carrier protein Myristoyl-ACP (n-C14:0ACP)
acyl carrier protein Hexadecenoyl-ACP (n-C16:1ACP)
acyl carrier protein R-3-hydroxy-myristoyl-ACP
acyl carrier protein Tetradecenoyl-ACP (n-C14:1ACP)
acyl carrier protein Octadecenoyl-ACP (n-C18:1ACP)
acyl carrier protein Dodecanoyl-ACP (n-C12:0ACP)
acyl carrier protein Palmitoyl-ACP (n-C16:0ACP)
O2 Hydrogen peroxide
D-Glucose Maltohexaose
D-Glucose Maltopentaose
D-Glucose Maltose
D-Glucose Maltotetraose
D-Glucose Maltotriose
Ubiquinol-8 Ubiquinone-8
Menaquinone 8 Menaquinol 8
Succinate Fumarate
L-Aspartate L-Asparagine
CMP CDPdiacylglycerol (E coli)
CMP CMP-3-deoxy-D-manno-octulosonate
2-Demethylmenaquinone 8 2-Demethylmenaquinol 8
GTP GDP
Malonyl-[acyl-carrier protein] Acetoacetyl-ACP
Oxaloacetate L-Malate
Reduced thioredoxin Oxidized thioredoxin
Glyoxylate Glycolate
Flavin adenine dinucleotide oxidized Flavin adenine dinucleotide reduced
S-Adenosyl-L-methionine S-Adenosyl-L-homocysteine
tetradecanoate (n-C14:0) Hexadecanoate (n-C16:0)
tetradecanoate (n-C14:0) tetradecenoate (n-C14:1)
tetradecanoate (n-C14:0) hexadecenoate (n-C16:1)
tetradecanoate (n-C14:0) octadecenoate (n-C18:1)
Hexadecanoate (n-C16:0) tetradecenoate (n-C14:1)
Hexadecanoate (n-C16:0) hexadecenoate (n-C16:1)
Hexadecanoate (n-C16:0) octadecenoate (n-C18:1)
5,6,7,8-Tetrahydrofolate 5,10-Methylenetetrahydrofolate
5,6,7,8-Tetrahydrofolate 10-Formyltetrahydrofolate
tetradecenoate (n-C14:1) hexadecenoate (n-C16:1)
tetradecenoate (n-C14:1) octadecenoate (n-C18:1)
hexadecenoate (n-C16:1) octadecenoate (n-C18:1)
hexadecenoate (n-C16:1) acyl-glycerophosphoglycerol (E.coli)
octadecenoate (n-C18:1) acyl-glycerophosphocholine
UDPglucose UDPgalactose
Maltohexaose Maltopentaose
Maltohexaose Maltoheptaose
Phosphatidylglycerol (Ecoli) acyl phosphatidylglycerol (E.coli)
Maltopentaose Maltotetraose
Pyridoxal 5'-phosphate Pyridoxamine 5'-phosphate
Pyridoxal 5'-phosphate Pyridoxal
NMN Nicotinamide
Reduced glutathione Glutathionylspermidine
Reduced glutathione (R)-S-Lactoylglutathione
Isopentenyl diphosphate Farnesyl diphosphate
Isopentenyl diphosphate Dimethylallyl diphosphate
Isopentenyl diphosphate Geranyl diphosphate
D-Gluconate 2-Dehydro-D-gluconate
Spermidine Glutathionylspermidine
3-Methyl-2-oxobutanoate L-Valine
CMP-3-deoxy-D-manno-octulosonate KDO-lipid IV(A)
Trimethylamine N-oxide trimethylamine
Dimethyl sulfoxide Dimethyl sulfide
alpha,alpha'-Trehalose 6-phosphate Trehalose
1-Pyrroline-5-carboxylate L-Proline
UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine 2,3-Bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate
acyl-glycerophosphoethanolamine (E.coli) sn-Glycero-3-phosphoethanolamine
acyl-glycerophosphoglycerol (E.coli) Glycerophosphoglycerol
Carnitinyl-CoA crotonobetainyl-CoA
Carnitinyl-CoA L-Carnitine
N-Acetyl-D-mannosamine 6-phosphate N-Acetyl-D-mannosamine
2-keto-4-methylthiobutyrate 2,3-diketo-5-methylthio-1-phosphopentane
Biotin d-biotin d-sulfoxide
Nitrite Nitrate
N1-(5-Phospho-D-ribosyl)glycinamide N2-Formyl-N1-(5-phospho-D-ribosyl)glycinamide
Orotate (S)-Dihydroorotate
4-(1-D-Ribitylamino)-5-aminouracil 6,7-Dimethyl-8-(1-D-ribityl)lumazine
Glycine betaine Betaine aldehyde
L-Glutamyl-tRNA(Glu) tRNA (Glu)