From: Selection of antisense oligonucleotides based on multiple predicted target mRNA structures
Parameter | Definition |
---|---|
f NS | Number of bases in single-stranded region |
f NP | Number of bases in double-stranded region |
f PS | Percentage of bases in single-stranded region to the length of ODN |
f PP | Percentage of bases in double-stranded region to the length of ODN |
f CS | Maximum length of consecutive subsequence in single-stranded region |
f CP | Maximum length of consecutive subsequence in base pairing |
f 5S | Maximum length of consecutive subsequence in single-stranded region counting from 5' terminal |
f 5P | Maximum length of consecutive subsequence in base pairing counting from 5' terminal |
f 3S | Maximum length of consecutive subsequence in single-stranded region counting from 3' terminal |
f 3P | Maximum length of consecutive subsequence in base pairing counting from 3' terminal |
f SC | Structure consistency, , where |