Observed Correlations. The observed correlations between interactions and evolutionary rate in three datasets. Correlations were statistically quantified using Spearman's rank correlation coefficient. A The correlation observed in the DIP_Core dataset ρ: -0.16819. Grishin's method was used to obtain evolutionary rate. B No correlation was observed in the INTACT_ITO dataset ρ: 0.03 C The INTACT_HO dataset showed our strongest correlation ρ: -0.227. Proteins with more than 100 interactions are not shown on the figures to aid clarity.