Table 1 Datasets and their correlations. The different datasets that were used in the study and the number of their constituent proteins and interactions. The total number of proteins is shown, as well as the number of proteins for which sequence information was obtainable and the number of orthologs found in the Mus musculus. The final four columns show the correlations between three factors, Evolutionary Distance (ED) as measured using Grishin's method, Abundance (A) and Number of interactions (I). P-values for these correlations were calculated, values in bold have a p-value greater than 0.03. The final column shows the result of a partial correlation, between evolutionary rate and number of interactions where abundance has been controlled for. The BIND datasets lacked expression information due to nomenclature issues.
From: Protein protein interactions, evolutionary rate, abundance and age
Dataset | Number of Proteins | Number of Interactions | ED vs I | ED vs A | A vs I | ED vs I. controled A | ||
|---|---|---|---|---|---|---|---|---|
| Â | Total | Sequences | Orthologs | Â | Â | Â | Â | Â |
MIPS_GENETIC | 1628 | 1618 | 903 | 5113 | 0.005 | -0.4381 | 0.018 | 0.015 |
MIPS_PHYSICAL | 4154 | 4124 | 2064 | 7458 | -0.017 | -0.410 | -0.064 | -0.048 |
BIND | 4542 | 3999 | 2084 | 8649 | -0.032 | - | - | - |
GRID | 4907 | 4897 | 2381 | 17598 | -0.118 | -0.416 | 0.135 | -0.069 |
MINT | 4595 | 4590 | 2269 | 12582 | -0.143 | -0.407 | 0.174 | -0.080 |
DIP_FULL | 4773 | 4772 | 2354 | 15481 | -0.121 | -0.411 | 0.164 | -0.059 |
DIP_CORE | 2640 | 2640 | 1552 | 6600 | -0.168 | -0.397 | 0.176 | -0.109 |
INTACT_UETZ | 1328 | 1325 | 816 | 1438 | -0.077 | -0.391 | -0.045 | -0.103 |
INTACT_ITO | 3245 | 3241 | 1675 | 4449 | 0.030 | -0.4172 | 0.001 | 0.033 |
INTACT_GAVIN | 1471 | 1467 | 1014 | 3957 | -0.172 | -0.431 | 0.172 | -0.109 |
INTACT_SMALL | 94 | 92 | 63 | 134 | -0.208 | -0.087 | -0.122 | -0.221 |
INTACT_HO | 1577 | 1573 | 1036 | 3618 | -0.227 | -0.388 | 0.213 | -0.160 |