Skip to main content

Table 2 The top 10 matches to the BRC1_HUMAN gene after searching the UniProt human proteome with a D-value cutoff of 0.05 in the Biological Process Category (data source: DAG-Edit version 1.419 Rev 3 and EBI goa_human.28)

From: Gene functional similarity search tool (GFSST)

Protein Summary of functions D-value
BRCA1_HUMAN Plays a central role in DNA repair by facilitating cellular response to DNA repair 0.000000000
P53_HUMAN Acts as a tumor suppressor in many tumor types 0.0064676759
VHL_HUMAN Von Hippel-Lindau disease tumor suppressor 0.0094604740
P73_HUMAN Participates in the apoptotic response to DNA damage 0.0102616186
INHA_HUMAN Inhibin alpha chain [Precursor] 0.0119586522
INHBA_HUMAN Inhibin beta A chain [Precursor] 0.0119586522
CGRF1_HUMAN Cell growth regulator with RING finger domain 1 0.0120311036
MAT1_HUMAN CDK-activating kinase assembly factor MAT1 0.0189669271
PMS1_HUMAN Probably involved in the repair of mismatches in DNA 0.0191020767
RBBP8_HUMAN Retinoblastoma-binding protein 8 0.0191020767
IRF1_HUMAN Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes
(the interferon consensus sequence (ICS)) and activates those genes.