Table 4 The prediction performance of Scansite, NetPhosK, KinasePhos and GPS for four well-studied PKs of PKA, CK2, ATM and S6K.

Predictor

Sn(%)

Sp(%)

MCC

Sn(%)

Sp(%)

MCC

Sn(%)

Sp(%)

MCC

Sn(%)

Sp(%)

MCC

PPSP

Default^a

90.11

91.7

0.3841

83.21

90.01

0.3596

93.02

94.06

0.4627

92.85

97.97

0.6618

ScanSite

High^b

21.98

99.96

0.4450

10.95

99.86

0.2655

18.6

99.8

0.3443

N/A

N/A

N/A

Medium

44.51

99.39

0.5084

27.01

99.11

0.3342

25.58

98.89

0.2756

N/A

N/A

N/A

Low

47.8

98.29

0.4041

54.02

96.34

0.3684

51.16

94.89

0.2739

N/A

N/A

N/A

NetPhosK

Default

79.12

90.65

0.3165

82.48

89.43

0.3464

86.01

98.51

0.6786

82.35

97.14

0.5404

KinasePhos

90% (Sp)^d

90.72

91.3

0.3783

72.53

91.58

0.3384

88.37

87.8

0.3137

N/A

N/A

N/A

95% (Sp)

89.18

94.62

0.4595

64.58

94.93

0.3806

88.37

92.14

0.3893

N/A

N/A

N/A

100% (Sp)

76.8

98.47

0.6154

54.86

98.66

0.5222

86.05

96.89

0.5497

N/A

N/A

N/A

GPS

Default

88.88

90.57

0.3564

82.99

87.59

0.3210

90.86

89.55

0.3498

94.9

91.34

0.3964