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Table 3 Top ranking candidate genes for 'Hypertension'. The list was complied on the basis of the overlap of the disease concept profile with those of the individual genes. 'Candidate SNPs' shows the number SNPs classified as deleterious in each gene. The 'OMIM' column indicates which genes are associated with essential hypertension in that database. The 'GAD' column shows the number of votes for or against a role for each gene in hypertension in the Genetic Association Database [47].

From: SNPs3D: Candidate gene and SNP selection for association studies

Gene Symbol

Candidate SNPs

OMIM

GAD

AGT

1

Y

N3/Y19

ACE

6

 

N6/Y24

AGTR1

2

Y

Y11

GNB3

2

Y

N1/Y6

HSD11B2

1

 

Y1

CYP11B2

2

 

N1/Y2

BMPR2

0

  

ADD1

1

Y

N5/Y4

REN

3

 

Y3

EDN1

0

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