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Table 4 Example candidate SNPs for hypertension

From: SNPs3D: Candidate gene and SNP selection for association studies

RefSNP ID

Gene Name

Refseq Protein

SNP

SVM profile

SVM structure

Structure and Sequence Properties

dbSNP ID and Population Frequency

rs11571098

REN

NP_000528

R33W

-1.63

-0.21

Salt Bridge lost

ss20420843:4% (African American)

rs4976

ACE

NP_690044

I444T

-1.26

-1.15

Hydrophobic Interaction loss

ss6413:5% (Multination) [76]

rs5247

CMA1

NP_001827

H66R

-2.51

-1.49

Salt Bridge lost; key catalytic residue, very conserved

ss6694:10% (Multination) [76]

rs5518

KLK1

NP_002248

V193E

-1.62

-0.70

Buried Charge, hydrophobic interaction decreased

ss6984:5% (Multination) [76]