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Table 3 Selectivity recognition map predicted from binary model. Selectivity recognition map for wild-type MC receptor pairs for α-MSH computed from the binary proteochemometric model. The contribution to the selectivity Su, log(M), for indicated segments S1–S5, was computed from the model using Eq. 5. Total selectivity represents the entire differences in affinity between receptor pairs computed from the model (see Eq. 4).

From: Prediction of indirect interactions in proteins

Segment Contribution to selectivity Su, (log(M))
  MC1/MC3 MC1/MC4 MC1/MC5 MC3/MC4 MC3/MC5 MC4/MC5
S1 1.14 1.07 1.04 -0.07 -0.09 -0.02
S2 0.39 0.91 1.15 0.52 0.77 0.24
S3 -0.15 0.33 0.44 0.49 0.60 0.11
S4 -0.07 0.54 0.62 0.61 0.69 0.08
S5 0.10 0.29 0.46 0.19 0.36 0.17
Total selectivity 1.40253 3.1389 3.71986 1.73638 2.31735 0.58095