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Table 3 Selectivity recognition map predicted from binary model. Selectivity recognition map for wild-type MC receptor pairs for α-MSH computed from the binary proteochemometric model. The contribution to the selectivity Su, log(M), for indicated segments S1–S5, was computed from the model using Eq. 5. Total selectivity represents the entire differences in affinity between receptor pairs computed from the model (see Eq. 4).

From: Prediction of indirect interactions in proteins

Segment

Contribution to selectivity Su, (log(M))

 

MC1/MC3

MC1/MC4

MC1/MC5

MC3/MC4

MC3/MC5

MC4/MC5

S1

1.14

1.07

1.04

-0.07

-0.09

-0.02

S2

0.39

0.91

1.15

0.52

0.77

0.24

S3

-0.15

0.33

0.44

0.49

0.60

0.11

S4

-0.07

0.54

0.62

0.61

0.69

0.08

S5

0.10

0.29

0.46

0.19

0.36

0.17

Total selectivity

1.40253

3.1389

3.71986

1.73638

2.31735

0.58095