Figure 3

Transformed gene expression profiles. Four gene expression profiles across six experiments are depicted. The CORE algorithm uses two parameters, β _i and γ _i , for each gene to reflect linear transformations of a gene's expression profile. The parameter β represents multiplicative scaling and the parameter γ represents additive translation. In the figure, the expression profile for g _x is a translated version (β = 1, γ = -1) of the profile for g _w , and the profile for g _y is a scaled version (β = 2, γ = 0) of that for g _w . Thus, the three expression profiles, g _w , g _x and g _y , have the same shape, and all three are perfectly correlated, i.e., have a distance of zero from each other in the CORE algorithm. In contrast, the profiles for g _w and g _z have different shapes but are the closest in terms of Euclidean distance.