Figure 1
From: Automatic pathway building in biological association networks
Examples of the coherent loops used for automatic ResNet curation. Node TF represents a transcription factor. Green arrows – PromoterBinding relations, blue arrow – Expression relation, grey arrow – Regulation, Brown arrow – MolSynthesis. The coherent loop conversion rule converts the expression link from Regulator node to Target node into Regulation link. Arrow with "+" indicate positive regulation and negative regulation is shown as "---|". A. Coherent loop with all relation having positive effect. Regulator->TF: positive; TF->Target: positive; Regulator->Target: positive; B. Coherent loop with negative effects. Regulator->TF: positive; TF->Target: negative. Regulator->Target: negative. Other two types of coherent loops have following configurations: Regulator->TF: negative; TF->Target: positive; Regulator->Target: negative. Regulator->TF: negative; TF->Target: negative; Regulator->Target: positive.