Increase in the number of pathways predicted for tissue-specific ligands in different tissue types. The number of pathways is normalized to the number of tissues in every tissue type. Twenty-one immune tissues names listed in : Appendix, BM-CD105+Endothelial, BM-CD33+Myeloid, BM-CD34+, BM-CD71+Early Erythroid, Bone marrow, Burkitts-Daudi lymphoma, Burkitts-Raji lymphoma, Leukemia chronic myelogenous(k562), Leukemia lymphoblastic(molt4), Leukemia promyelocytic(hl60), Lymphnode, Lymphoblasts, PB-BDCA4+Dentritic, PB-CD14+Monocytes, PB-CD19+Bcells, PB-CD4+Tcells, PB-CD56+NKCells, PB-CD8+Tcells, Thymus, Whole blood. Twenty-three CNS tissues names listed in : Amygdala, Caudate nucleus, Cerebellum, Cerebellum peduncles, Ciliary ganglion, Cingulate cortex, DRG, Fetal brain, Globus pallidus, Hypothalamus, Medulla oblongata, Occipital lobe, Olfactory bulb, Parietal lobe, Pituitary, Pons, Prefrontal cortex, Subthalamic nucleus, Superior Cervical Ganglion, Temporal lobe, Thalamus, Trigeminal ganglion, Whole Brain. 8 CNS specific ligands from ResNet database: BDNF (brain derived neurotrophic factor), CNTF (ciliary neurotrophic factor), GDNF (glial cell line derived neurotrophic factor), GPI autocrine motility factor, leptin, NGFB (nerve growth factor beta), NPTX1 (neuronal pentraxin I), NTF3 (neurotrophin 3). List of 36 immunological ligands is not shown.