Figure 4From: Identifying metabolic enzymes with multiple types of association evidenceEnzyme predictions based on individual and combined types of association evidence (see Methods, Table 1). Fraction of known enzymes predicted within different self-rank thresholds is shown for a. E. coli metabolism and b. S. cerevisiae metabolism. Each curve indicates a probability (y axis) with which a true enzyme-encoding gene will be predicted within top n (x axis) candidates for its enzymatic function. The total number of candidates is 3352 for E. coli and 5253 for S. cerevisiae. Different curves demonstrate predictive performance of various types of association evidence. Predictions are generated based on functional association with the first three layers of the metabolic network neighborhood, using ADT classifier with 10-fold validation.Back to article page