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Table 3 Standard deviations of elementary mode fluxes under variation of single kinetic parameters, and elasticity coefficients of parameters at the experimental steady state

From: Quantitative elementary mode analysis of metabolic pathways: the example of yeast glycolysis

Enzyme Parameter EM1 EM2 EM3 EM4 EM5 EM6 EM7 EM8 Elasticity
GLK V max 0 0 0 0 0.12 0 0.58 4.01 1.0
  K eq 0 0 0 0.21 0.48 0 1.85 8.94 0.0014
  K m·Glc 0 0 0 0.23 0.58 0 2.30 12.02 -0.456
  K m·G6P 0 0 0 0.21 0.52 0 1.99 9.80 0.015
  K m·ATP 0 0 0 0 0.05 0 0.27 1.91 -0.283
  K m·ADP 0 0 0 0 0.06 0 0.31 2.15 0.241
PGI V max 0 0 0 0.27 0.62 0 2.30 10.12 1.0
  K eq 0 0 0 0 0.05 0 0.27 1.90 0.533
  K m·G6P 0 0 0 0 0.04 0 0.21 1.48 -0.651
  K m·F6P 0 0 0 0 0.04 0 0.01 0.02 0.178
PFK V max 0 0 0 0.09 0.29 0 1.17 6.27 1.0
  g R 0 0 0 0 0.01 0 0.05 0.32 0.937
  L 0 0 0 0 0 0.10 0 0.50 3.53 -0.460
  K m·ATP 0 0 0 0 0 0 0.01 0.06 -0.086
  K m·F6P 0 0 0 0 0.05 0 0.26 1.80 -0.934
  K AMP 0 0 0 0 0 0 0.02 0.15 -0.504
  K ATP 0 0 0 0 0 0 0.01 0.06 0.187
  K F2bP 0 0 0 0 0.01 0 0.03 0.18 -0.626
  K F16bP 0 0 0 0 0 0 0.02 0.16 0.401
ALD V max 0 0 0 0 0 0 0 0.03 1.0
  K eq 0 0 0 0 0 0 0.02 0.13 1.499
  K m·F16P 0 0 0 0 0 0 0.01 0.09 -0.398
  K m·GAP 0 0 0 0 0 0 0.01 0.10 0.0067
  K m·DHAP 0 0 0 0 0 0 0.02 0.11 0.094
  K m·GAPi 0 0 0 0 0 0 0 0.01 0.0020
G3PDH V max 0 0 0.87 1.96 1.24 0 7.65 13.74 1.0
  K eq 0 0 0 0 1.40 0 6.98 8.90 0.0016
  K m·DHAP 0 0 0 0.38 1.60 0 8.77 11.88 -0.382
  K m·NADH 0 0 0 1.87 1.28 0 8.50 13.81 -0.579
  K m·NAD 0 0 0 0.39 1.57 0 8.65 11.80 0.362
  K m·Gly 0 0 0 0 1.39 0 6.94 8.88 0.050
GAPDH V max 0 0 0 0.17 1.35 0 6.98 9.49 1.0
  K eq 0 0 0 0.10 1.25 0 6.37 8.66 0.880
  K m·GAP 0 0 0 0.12 1.48 0 7.58 10.23 -0.919
  K m·BPG 0 0 0 0 0.17 0 0.83 1.16 0.082
  K m·NAD 0 0 0 0.17 0.31 0 1.81 2.79 -0.145
  K m·NADH 0 0 0 0.15 0.30 0 1.67 2.53 0.092
PGK V max 0 0 0 0.02 0.23 0 1.17 1.70 1.0
  K eq 0 0 0 0.02 0.28 0 1.44 2.06 2.909
  K m·BPG 0 0 0 0 0.02 0 0.11 0.16 0.062
  K m·P3G 0 0 0 0.17 0.16 0 1.13 1.87 -0.623
  K m·ADP 0 0 0 0.06 0.18 0 1.07 1.63 0.408
  K m·ATP 0 0 0 0.15 0.18 0 1.17 1.90 -0.471
PGM V max 0 0 0.56 0.77 0.70 0 2.35 9.51 1.0
  K eq 0 0 0 0.06 0.29 0 1.56 2.28 1.959
  K m·P3G 0 0 0 0 0.25 0 1.27 1.81 -0.840
  K m·P2G 0 0 0 0.18 0.27 0 1.63 2.57 0.302
ENO V max 0 0 0 0 0.03 0 0.14 0.19 1.0
  K eq 0 0 0 0.10 0.27 0 1.48 2.22 0.325
  K m·P2G 0 0 0 0.06 0.28 0 1.50 2.19 -0.506
  K m·PEP 0 0 0 0.25 0.27 0 1.75 2.87 0.065
PYK V max 0 0 0 0 0.08 0 0.40 0.56 1.0
  K eq 0 0 0 0.23 0.28 0 1.76 2.85 0.036
  K m·PEP 0 0 0 0 0.16 0 0.82 1.15 -0.728
  K m·Pyr 0 0 0 0 0.15 0 0.73 1.02 0.210
  K m·ADP 0 0 0 0 0.17 0 0.84 1.19 -0.523
  K m·ATP 0 0 0 0 0.02 0 0.08 0.13 0.327
PDC V max 0 0 0 0 0 0 0.02 0.02 1.0
  K m·Pyr 0 0 0 0 0.02 0 0.09 0.13 -0.411
ADH V max 0 0 0 0.05 0.37 0 1.94 2.70 1.0
  K eq 0 0 0 1.26 1.33 0 7.80 11.76 -3.393
  K m·Ace 0 0 0.76 1.53 0.61 0 1.61 5.80 0.139
  K m·Et 0 0 1.00 1.77 0.79 0 1.72 7.84 -0.457
  K m·NADH 0 0 0 0.37 0.23 0 1.54 2.62 -0.113
  K m·NADP 0 0 0.97 1.84 0.83 0 1.74 7.24 -0.102