Quantitative elementary mode analysis of metabolic pathways: the example of yeast glycolysis

Schwartz, Jean-Marc; Kanehisa, Minoru

doi:10.1186/1471-2105-7-186

BMC Bioinformatics

Table 3 Standard deviations of elementary mode fluxes under variation of single kinetic parameters, and elasticity coefficients of parameters at the experimental steady state

From: Quantitative elementary mode analysis of metabolic pathways: the example of yeast glycolysis

Enzyme	Parameter	EM3	EM4	EM5	EM7	EM8	Elasticity
GLK	V _max	0	0	0.12	0.58	4.01	1.0
	K _eq	0	0.21	0.48	1.85	8.94	0.0014
	K _m·Glc	0	0.23	0.58	2.30	12.02	-0.456
	K _m·G6P	0	0.21	0.52	1.99	9.80	0.015
	K _m·ATP	0	0	0.05	0.27	1.91	-0.283
	K _m·ADP	0	0	0.06	0.31	2.15	0.241
PGI	V _max	0	0.27	0.62	2.30	10.12	1.0
	K _eq	0	0	0.05	0.27	1.90	0.533
	K _m·G6P	0	0	0.04	0.21	1.48	-0.651
	K _m·F6P	0	0	0.04	0.01	0.02	0.178
PFK	V _max	0	0.09	0.29	1.17	6.27	1.0
	g _R	0	0	0.01	0.05	0.32	0.937
	L ₀	0	0	0.10	0.50	3.53	-0.460
	K _m·ATP	0	0	0	0.01	0.06	-0.086
	K _m·F6P	0	0	0.05	0.26	1.80	-0.934
	K _AMP	0	0	0	0.02	0.15	-0.504
	K _ATP	0	0	0	0.01	0.06	0.187
	K _F2bP	0	0	0.01	0.03	0.18	-0.626
	K _F16bP	0	0	0	0.02	0.16	0.401
ALD	V _max	0	0	0	0	0.03	1.0
	K _eq	0	0	0	0.02	0.13	1.499
	K _m·F16P	0	0	0	0.01	0.09	-0.398
	K _m·GAP	0	0	0	0.01	0.10	0.0067
	K _m·DHAP	0	0	0	0.02	0.11	0.094
	K _m·GAPi	0	0	0	0	0.01	0.0020
G3PDH	V _max	0.87	1.96	1.24	7.65	13.74	1.0
	K _eq	0	0	1.40	6.98	8.90	0.0016
	K _m·DHAP	0	0.38	1.60	8.77	11.88	-0.382
	K _m·NADH	0	1.87	1.28	8.50	13.81	-0.579
	K _m·NAD	0	0.39	1.57	8.65	11.80	0.362
	K _m·Gly	0	0	1.39	6.94	8.88	0.050
GAPDH	V _max	0	0.17	1.35	6.98	9.49	1.0
	K _eq	0	0.10	1.25	6.37	8.66	0.880
	K _m·GAP	0	0.12	1.48	7.58	10.23	-0.919
	K _m·BPG	0	0	0.17	0.83	1.16	0.082
	K _m·NAD	0	0.17	0.31	1.81	2.79	-0.145
	K _m·NADH	0	0.15	0.30	1.67	2.53	0.092
PGK	V _max	0	0.02	0.23	1.17	1.70	1.0
	K _eq	0	0.02	0.28	1.44	2.06	2.909
	K _m·BPG	0	0	0.02	0.11	0.16	0.062
	K _m·P3G	0	0.17	0.16	1.13	1.87	-0.623
	K _m·ADP	0	0.06	0.18	1.07	1.63	0.408
	K _m·ATP	0	0.15	0.18	1.17	1.90	-0.471
PGM	V _max	0.56	0.77	0.70	2.35	9.51	1.0
	K _eq	0	0.06	0.29	1.56	2.28	1.959
	K _m·P3G	0	0	0.25	1.27	1.81	-0.840
	K _m·P2G	0	0.18	0.27	1.63	2.57	0.302
ENO	V _max	0	0	0.03	0.14	0.19	1.0
	K _eq	0	0.10	0.27	1.48	2.22	0.325
	K _m·P2G	0	0.06	0.28	1.50	2.19	-0.506
	K _m·PEP	0	0.25	0.27	1.75	2.87	0.065
PYK	V _max	0	0	0.08	0.40	0.56	1.0
	K _eq	0	0.23	0.28	1.76	2.85	0.036
	K _m·PEP	0	0	0.16	0.82	1.15	-0.728
	K _m·Pyr	0	0	0.15	0.73	1.02	0.210
	K _m·ADP	0	0	0.17	0.84	1.19	-0.523
	K _m·ATP	0	0	0.02	0.08	0.13	0.327
PDC	V _max	0	0	0	0.02	0.02	1.0
	K _m·Pyr	0	0	0.02	0.09	0.13	-0.411
ADH	V _max	0	0.05	0.37	1.94	2.70	1.0
	K _eq	0	1.26	1.33	7.80	11.76	-3.393
	K _m·Ace	0.76	1.53	0.61	1.61	5.80	0.139
	K _m·Et	1.00	1.77	0.79	1.72	7.84	-0.457
	K _m·NADH	0	0.37	0.23	1.54	2.62	-0.113
	K _m·NADP	0.97	1.84	0.83	1.74	7.24	-0.102

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ISSN: 1471-2105

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