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Table 4 PC21 Low Extreme Genes. Detailed info for (n = 49) extreme genes in PC21 set L 21 , ordered most extreme first, including common name, description, and associated Gene Ontology terms (provided with the GNF dataset). These extreme genes are shown as blue points in Figure 3.

From: Mining gene expression data by interpreting principal components

PC-21 Value Name Description Function
-11.74 Ckm creatine kinase, muscle creatine kinase activity (GO:0004111); transferase activity, transferring phosphorus-containing groups (GO:0016772)
-11.61 ACTA1 actin, alpha 1, skeletal muscle motor activity (GO:0003774);muscle contraction (GO:0006936);muscle development (GO:0007517);structural constituent of cytoskeleton (GO:0005200)
-10.27 MYH7 myosin, heavy polypeptide 7, cardiac muscle, beta ATP binding (GO:0005524);actin binding (GO:0003779);calmodulin binding (GO:0005516);microfilament motor activity (GO:0000146);motor activity (GO:0003774);muscle contraction (GO:0006936);muscle development (GO:0007517);protein amino acid alkylation (GO:0008213);striated muscle contraction (GO:0006941);structural constituent of muscle (GO:0008307)
-10.01 TPM1 tropomyosin 1 (alpha) actin binding (GO:0003779);muscle development (GO:0007517);regulation of heart rate (GO:0008016);structural constituent of cytoskeleton (GO:0005200);structural constituent of muscle (GO:0008307)
-9.10 MYL1 myosin, light polypeptide 1, alkali; skeletal, fast calcium ion binding (GO:0005509);muscle development (GO:0007517);structural constituent of muscle (GO:0008307)
-9.10 TNNC1 troponin C, slow calcium ion binding (GO:0005509);muscle development (GO:0007517)
-8.92 PPP1R1A protein phosphatase 1, regulatory (inhibitor) subunit 1A glycogen metabolism (GO:0005977);protein phosphatase inhibitor activity (GO:0004864);signal transduction (GO:0007165);type 1 serine/threonine specific protein phosphatase inhibitor activity (GO:0004865)
-8.79 TNNC2 troponin C2, fast calcium ion binding (GO:0005509);muscle development (GO:0007517)
-8.71 TNNT1 troponin T1, skeletal, slow muscle development (GO:0007517);tropomyosin binding (GO:0005523)
-8.70 KRT14 keratin 14 (epidermolysis bullosa simplex, Dowling-Meara, Koebner) biological_process unknown (GO:0000004);structural constituent of cytoskeleton (GO:0005200);structural constituent of epidermis (GO:0030280)
-8.67 TTID titin immunoglobulin domain protein (myotilin) muscle contraction (GO:0006936);protein binding- (GO:0005515);structural constituent of muscle (GO:0008307)
-8.49 HUMMLC2B myosin light chain 2 calcium ion binding (GO:0005509);structural constituent of muscle (GO:0008307)
-8.35 TRIM T-cell receptor interacting molecule DNA binding (GO:0003677);cellular defense response (GO:0006968);signal transduction (GO:0007165);transmembrane receptor protein tyrosine kinase adaptor protein activity (GO:0005068)
-8.20 TTN titin ATP binding (GO:0005524);calmodulin binding (GO:0005516);cation transporter activity (GO:0008324);hematopoietin/interferon-class (D200-domain) cytokine receptor activity (GO:0004896);muscle development (GO:0007517);myosin binding (GO:0017022);protein amino acid phosphorylation (GO:0006468);protein serine/threonine kinase activity (GO:0004674);regulation of actin filament length (GO:0030832);somatic muscle development (GO:0007525);striated muscle contraction (GO:0006941);structural constituent of muscle (GO:0008307);structural molecule activity (GO:0005198);transferase activity (GO:0016740)
-7.91 CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein) None
-7.66 MB myoglobin electron transporter activity (GO:0005489);globin (GO:0001524);oxygen transport (GO:0015671);oxygen transporter activity (GO:0005344);transport (GO:0006810)
-7.46 ENO3 enolase 3, (beta, muscle) glycolysis (GO:0006096);lyase activity (GO:0016829);magnesium ion binding (GO:0000287);phosphopyruvate hydratase activity (GO:0004634)
-7.32 NTRK2 neurotrophic tyrosine kinase, receptor, type 2 ATP binding (GO:0005524);kinase activity (GO:0016301);neurogenesis (GO:0007399);neurotrophin TRKB receptor activity (GO:0005015);neurotrophin binding (GO:0043121);protein amino acid phosphorylation (GO:0006468);receptor activity (GO:0004872);transferase activity (GO:0016740);transmembrane receptor protein tyrosine kinase activity (GO:0004714);transmembrane receptor protein tyrosine kinase signaling pathway (GO:0007169)
-7.28 MYL2 myosin, light polypeptide 2, regulatory, cardiac, slow calcium ion binding (GO:0005509);muscle development (GO:0007517);structural constituent of muscle (GO:0008307)
-7.27 TF Transferring ferric iron binding (GO:0008199);iron ion binding (GO:0005506);iron ion homeostasis (GO:0006879);iron ion transport (GO:0006826);transport (GO:0006810)
-7.16 ACSL1 acyl-CoA synthetase long-chain family member 1 digestion (GO:0007586);fatty acid metabolism (GO:0006631);ligase activity (GO:0016874);long-chain-fatty-acid-CoA ligase activity (GO:0004467);magnesium ion binding (GO:0000287);metabolism (GO:0008152)
-7.10 MYBPC1 myosin binding protein C, slow type actin binding (GO:0003779);cell adhesion (GO:0007155);cell adhesion molecule activity (GO:0005194);muscle development (GO:0007517);protein binding (GO:0005515);striated muscle contraction (GO:0006941);structural constituent of muscle (GO:0008307)
-7.07 S100A2 S100 calcium binding protein A2 biological_process unknown (GO:0000004);calcium ion binding (GO:0005509)
-7.07 PYGM phosphorylase, glycogen; muscle (McArdle syndrome, glycogen storage disease type V) amino acid metabolism (GO:0006520);carbohydrate metabolism (GO:0005975);glycogen metabolism (GO:0005977);glycogen phosphorylase activity (GO:0008184);transferase activity, transferring glycosyl groups (GO:0016757)
-6.99 ACTN2 actinin, alpha 2 actin binding (GO:0003779);calcium ion binding (GO:0005509);protein binding (GO:0005515);structural constituent of muscle (GO:0008307)
-6.76 MYBPC2 myosin binding protein C, fast type actin binding (GO:0003779);cell adhesion (GO:0007155);cell adhesion molecule activity (GO:0005194);muscle development (GO:0007517);protein binding (GO:0005515);striated muscle contraction (GO:0006941);structural constituent of muscle (GO:0008307)
-6.71 UCP2 uncoupling protein 2 (mitochondrial, proton carrier) binding (GO:0005488);mitochondrial transport (GO:0006839);proton transport (GO:0015992);small molecule transport (GO:0006832);transport (GO:0006810);transporter activity (GO:0005215);uncoupling protein activity (GO:0015302)
-6.63 NEB nebulin actin binding (GO:0003779);muscle development (GO:0007517);regulation of actin filament length (GO:0030832);somatic muscle development (GO:0007525);structural constituent of muscle (GO:0008307)
-6.60 IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial carbohydrate metabolism (GO:0005975);glyoxylate cycle (GO:0006097);isocitrate dehydrogenase (NADP+) activity (GO:0004450);main pathways of carbohydrate metabolism (GO:0006092);metabolism (GO:0008152);oxidoreductase activity (GO:0016491);tricarboxylic acid cycle (GO:0006099)
-6.47 CSTA cystatin A (stefin A) cysteine protease inhibitor activity (GO:0004869);endopeptidase inhibitor activity (GO:0004866)
-6.45 MYH2 myosin, heavy polypeptide 2, skeletal muscle, adult ATP binding (GO:0005524);actin binding (GO:0003779);calmodulin binding (GO:0005516);microfilament motor activity (GO:0000146);motor activity (GO:0003774);muscle contraction (GO:0006936);muscle development (GO:0007517);muscle motor activity (GO:0003776);protein amino acid alkylation (GO:0008213);striated muscle contraction (GO:0006941)
-6.42 KRT4 keratin 4 cytoskeleton organization and biogenesis (GO:0007010);structural constituent of cytoskeleton (GO:0005200);structural molecule activity (GO:0005198)
-6.40 CLIC6 chloride intracellular channel 6 chloride transport (GO:0006821);ion transport (GO:0006811);voltage-gated chloride channel activity (GO:0005247)
-6.27 SPRR1A small proline-rich protein 1A structural molecule activity (GO:0005198)
-6.25 TNNI2 troponin I, skeletal, fast actin binding (GO:0003779);muscle development (GO:0007517)
-6.22 TNNI1 troponin I, skeletal, slow actin binding (GO:0003779);muscle development (GO:0007517);tropomyosin binding (GO:0005523)
-6.17 LDB3 LIM domain binding 3 electron transport (GO:0006118);electron transporter activity (GO:0005489);protein binding (GO:0005515)
-6.14 CRYAB crystallin, alpha B chaperone activity (GO:0003754);muscle contraction (GO:0006936);protein folding (GO:0006457);structural constituent of eye lens (GO:0005212);visual perception (GO:0007601)
-6.12 HFL1 H factor (complement)-like 1 plasma protein (GO:0005209)
-6.15 S100A1 S100 calcium binding protein A1 calcium ion binding (GO:0005509);cell communication (GO:0007154);intracellular signaling cascade (GO:0007242);neurogenesis (GO:0007399);protein binding (GO:0005515);zinc ion binding (GO:0008270)
-6.09 HSPB8 heat shock 22 kDa protein 8 biological_process unknown (GO:0000004);heat shock protein activity (GO:0003773);protein serine/threonine kinase activity (GO:0004674);transferase activity (GO:0016740)
-5.93 PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2) None
-5.88 GHR growth hormone receptor endocytosis (GO:0006897);growth hormone receptor activity (GO:0004903);growth pattern (GO:0007150);receptor activity (GO:0004872);skeletal development (GO:0001501)
-5.85 ACSL1 acyl-CoA synthetase long-chain family member 1 digestion (GO:0007586);fatty acid metabolism (GO:0006631);ligase activity (GO:0016874);long-chain-fatty-acid-CoA ligase activity (GO:0004467);magnesium ion binding (GO:0000287);metabolism (GO:0008152)
-5.84 MGC42493 hypothetical protein MGC42493 nucleic acid binding (GO:0003676);zinc ion binding (GO:0008270)
-5.73 SCD stearoyl-CoA desaturase (delta-9-desaturase) fatty acid biosynthesis (GO:0006633);iron ion binding (GO:0005506);oxidoreductase activity (GO:0016491);stearoyl-CoA 9-desaturase activity (GO:0004768)
-5.67 hIAN2 human immune associated nucleotide 2 GTP binding (GO:0005525)
-5.65 PDE4DIP phosphodiesterase 4D interacting protein (myomegalin) None
-5.63 HBA2 hemoglobin, alpha 2 oxygen transport (GO:0015671);oxygen transporter activity (GO:0005344);protein binding (GO:0005515);transport (GO:0006810)