Skip to main content

Table 4 PC21 Low Extreme Genes. Detailed info for (n = 49) extreme genes in PC21 set L 21 , ordered most extreme first, including common name, description, and associated Gene Ontology terms (provided with the GNF dataset). These extreme genes are shown as blue points in Figure 3.

From: Mining gene expression data by interpreting principal components

PC-21 Value

Name

Description

Function

-11.74

Ckm

creatine kinase, muscle

creatine kinase activity (GO:0004111); transferase activity, transferring phosphorus-containing groups (GO:0016772)

-11.61

ACTA1

actin, alpha 1, skeletal muscle

motor activity (GO:0003774);muscle contraction (GO:0006936);muscle development (GO:0007517);structural constituent of cytoskeleton (GO:0005200)

-10.27

MYH7

myosin, heavy polypeptide 7, cardiac muscle, beta

ATP binding (GO:0005524);actin binding (GO:0003779);calmodulin binding (GO:0005516);microfilament motor activity (GO:0000146);motor activity (GO:0003774);muscle contraction (GO:0006936);muscle development (GO:0007517);protein amino acid alkylation (GO:0008213);striated muscle contraction (GO:0006941);structural constituent of muscle (GO:0008307)

-10.01

TPM1

tropomyosin 1 (alpha)

actin binding (GO:0003779);muscle development (GO:0007517);regulation of heart rate (GO:0008016);structural constituent of cytoskeleton (GO:0005200);structural constituent of muscle (GO:0008307)

-9.10

MYL1

myosin, light polypeptide 1, alkali; skeletal, fast

calcium ion binding (GO:0005509);muscle development (GO:0007517);structural constituent of muscle (GO:0008307)

-9.10

TNNC1

troponin C, slow

calcium ion binding (GO:0005509);muscle development (GO:0007517)

-8.92

PPP1R1A

protein phosphatase 1, regulatory (inhibitor) subunit 1A

glycogen metabolism (GO:0005977);protein phosphatase inhibitor activity (GO:0004864);signal transduction (GO:0007165);type 1 serine/threonine specific protein phosphatase inhibitor activity (GO:0004865)

-8.79

TNNC2

troponin C2, fast

calcium ion binding (GO:0005509);muscle development (GO:0007517)

-8.71

TNNT1

troponin T1, skeletal, slow

muscle development (GO:0007517);tropomyosin binding (GO:0005523)

-8.70

KRT14

keratin 14 (epidermolysis bullosa simplex, Dowling-Meara, Koebner)

biological_process unknown (GO:0000004);structural constituent of cytoskeleton (GO:0005200);structural constituent of epidermis (GO:0030280)

-8.67

TTID

titin immunoglobulin domain protein (myotilin)

muscle contraction (GO:0006936);protein binding- (GO:0005515);structural constituent of muscle (GO:0008307)

-8.49

HUMMLC2B

myosin light chain 2

calcium ion binding (GO:0005509);structural constituent of muscle (GO:0008307)

-8.35

TRIM

T-cell receptor interacting molecule

DNA binding (GO:0003677);cellular defense response (GO:0006968);signal transduction (GO:0007165);transmembrane receptor protein tyrosine kinase adaptor protein activity (GO:0005068)

-8.20

TTN

titin

ATP binding (GO:0005524);calmodulin binding (GO:0005516);cation transporter activity (GO:0008324);hematopoietin/interferon-class (D200-domain) cytokine receptor activity (GO:0004896);muscle development (GO:0007517);myosin binding (GO:0017022);protein amino acid phosphorylation (GO:0006468);protein serine/threonine kinase activity (GO:0004674);regulation of actin filament length (GO:0030832);somatic muscle development (GO:0007525);striated muscle contraction (GO:0006941);structural constituent of muscle (GO:0008307);structural molecule activity (GO:0005198);transferase activity (GO:0016740)

-7.91

CSRP3

cysteine and glycine-rich protein 3 (cardiac LIM protein)

None

-7.66

MB

myoglobin

electron transporter activity (GO:0005489);globin (GO:0001524);oxygen transport (GO:0015671);oxygen transporter activity (GO:0005344);transport (GO:0006810)

-7.46

ENO3

enolase 3, (beta, muscle)

glycolysis (GO:0006096);lyase activity (GO:0016829);magnesium ion binding (GO:0000287);phosphopyruvate hydratase activity (GO:0004634)

-7.32

NTRK2

neurotrophic tyrosine kinase, receptor, type 2

ATP binding (GO:0005524);kinase activity (GO:0016301);neurogenesis (GO:0007399);neurotrophin TRKB receptor activity (GO:0005015);neurotrophin binding (GO:0043121);protein amino acid phosphorylation (GO:0006468);receptor activity (GO:0004872);transferase activity (GO:0016740);transmembrane receptor protein tyrosine kinase activity (GO:0004714);transmembrane receptor protein tyrosine kinase signaling pathway (GO:0007169)

-7.28

MYL2

myosin, light polypeptide 2, regulatory, cardiac, slow

calcium ion binding (GO:0005509);muscle development (GO:0007517);structural constituent of muscle (GO:0008307)

-7.27

TF

Transferring

ferric iron binding (GO:0008199);iron ion binding (GO:0005506);iron ion homeostasis (GO:0006879);iron ion transport (GO:0006826);transport (GO:0006810)

-7.16

ACSL1

acyl-CoA synthetase long-chain family member 1

digestion (GO:0007586);fatty acid metabolism (GO:0006631);ligase activity (GO:0016874);long-chain-fatty-acid-CoA ligase activity (GO:0004467);magnesium ion binding (GO:0000287);metabolism (GO:0008152)

-7.10

MYBPC1

myosin binding protein C, slow type

actin binding (GO:0003779);cell adhesion (GO:0007155);cell adhesion molecule activity (GO:0005194);muscle development (GO:0007517);protein binding (GO:0005515);striated muscle contraction (GO:0006941);structural constituent of muscle (GO:0008307)

-7.07

S100A2

S100 calcium binding protein A2

biological_process unknown (GO:0000004);calcium ion binding (GO:0005509)

-7.07

PYGM

phosphorylase, glycogen; muscle (McArdle syndrome, glycogen storage disease type V)

amino acid metabolism (GO:0006520);carbohydrate metabolism (GO:0005975);glycogen metabolism (GO:0005977);glycogen phosphorylase activity (GO:0008184);transferase activity, transferring glycosyl groups (GO:0016757)

-6.99

ACTN2

actinin, alpha 2

actin binding (GO:0003779);calcium ion binding (GO:0005509);protein binding (GO:0005515);structural constituent of muscle (GO:0008307)

-6.76

MYBPC2

myosin binding protein C, fast type

actin binding (GO:0003779);cell adhesion (GO:0007155);cell adhesion molecule activity (GO:0005194);muscle development (GO:0007517);protein binding (GO:0005515);striated muscle contraction (GO:0006941);structural constituent of muscle (GO:0008307)

-6.71

UCP2

uncoupling protein 2 (mitochondrial, proton carrier)

binding (GO:0005488);mitochondrial transport (GO:0006839);proton transport (GO:0015992);small molecule transport (GO:0006832);transport (GO:0006810);transporter activity (GO:0005215);uncoupling protein activity (GO:0015302)

-6.63

NEB

nebulin

actin binding (GO:0003779);muscle development (GO:0007517);regulation of actin filament length (GO:0030832);somatic muscle development (GO:0007525);structural constituent of muscle (GO:0008307)

-6.60

IDH2

isocitrate dehydrogenase 2 (NADP+), mitochondrial

carbohydrate metabolism (GO:0005975);glyoxylate cycle (GO:0006097);isocitrate dehydrogenase (NADP+) activity (GO:0004450);main pathways of carbohydrate metabolism (GO:0006092);metabolism (GO:0008152);oxidoreductase activity (GO:0016491);tricarboxylic acid cycle (GO:0006099)

-6.47

CSTA

cystatin A (stefin A)

cysteine protease inhibitor activity (GO:0004869);endopeptidase inhibitor activity (GO:0004866)

-6.45

MYH2

myosin, heavy polypeptide 2, skeletal muscle, adult

ATP binding (GO:0005524);actin binding (GO:0003779);calmodulin binding (GO:0005516);microfilament motor activity (GO:0000146);motor activity (GO:0003774);muscle contraction (GO:0006936);muscle development (GO:0007517);muscle motor activity (GO:0003776);protein amino acid alkylation (GO:0008213);striated muscle contraction (GO:0006941)

-6.42

KRT4

keratin 4

cytoskeleton organization and biogenesis (GO:0007010);structural constituent of cytoskeleton (GO:0005200);structural molecule activity (GO:0005198)

-6.40

CLIC6

chloride intracellular channel 6

chloride transport (GO:0006821);ion transport (GO:0006811);voltage-gated chloride channel activity (GO:0005247)

-6.27

SPRR1A

small proline-rich protein 1A

structural molecule activity (GO:0005198)

-6.25

TNNI2

troponin I, skeletal, fast

actin binding (GO:0003779);muscle development (GO:0007517)

-6.22

TNNI1

troponin I, skeletal, slow

actin binding (GO:0003779);muscle development (GO:0007517);tropomyosin binding (GO:0005523)

-6.17

LDB3

LIM domain binding 3

electron transport (GO:0006118);electron transporter activity (GO:0005489);protein binding (GO:0005515)

-6.14

CRYAB

crystallin, alpha B

chaperone activity (GO:0003754);muscle contraction (GO:0006936);protein folding (GO:0006457);structural constituent of eye lens (GO:0005212);visual perception (GO:0007601)

-6.12

HFL1

H factor (complement)-like 1

plasma protein (GO:0005209)

-6.15

S100A1

S100 calcium binding protein A1

calcium ion binding (GO:0005509);cell communication (GO:0007154);intracellular signaling cascade (GO:0007242);neurogenesis (GO:0007399);protein binding (GO:0005515);zinc ion binding (GO:0008270)

-6.09

HSPB8

heat shock 22 kDa protein 8

biological_process unknown (GO:0000004);heat shock protein activity (GO:0003773);protein serine/threonine kinase activity (GO:0004674);transferase activity (GO:0016740)

-5.93

PPFIBP2

PTPRF interacting protein, binding protein 2 (liprin beta 2)

None

-5.88

GHR

growth hormone receptor

endocytosis (GO:0006897);growth hormone receptor activity (GO:0004903);growth pattern (GO:0007150);receptor activity (GO:0004872);skeletal development (GO:0001501)

-5.85

ACSL1

acyl-CoA synthetase long-chain family member 1

digestion (GO:0007586);fatty acid metabolism (GO:0006631);ligase activity (GO:0016874);long-chain-fatty-acid-CoA ligase activity (GO:0004467);magnesium ion binding (GO:0000287);metabolism (GO:0008152)

-5.84

MGC42493

hypothetical protein MGC42493

nucleic acid binding (GO:0003676);zinc ion binding (GO:0008270)

-5.73

SCD

stearoyl-CoA desaturase (delta-9-desaturase)

fatty acid biosynthesis (GO:0006633);iron ion binding (GO:0005506);oxidoreductase activity (GO:0016491);stearoyl-CoA 9-desaturase activity (GO:0004768)

-5.67

hIAN2

human immune associated nucleotide 2

GTP binding (GO:0005525)

-5.65

PDE4DIP

phosphodiesterase 4D interacting protein (myomegalin)

None

-5.63

HBA2

hemoglobin, alpha 2

oxygen transport (GO:0015671);oxygen transporter activity (GO:0005344);protein binding (GO:0005515);transport (GO:0006810)