From: Mining gene expression data by interpreting principal components
PC-21 Value | Name | Description | Function |
---|---|---|---|
-11.74 | Ckm | creatine kinase, muscle | creatine kinase activity (GO:0004111); transferase activity, transferring phosphorus-containing groups (GO:0016772) |
-11.61 | ACTA1 | actin, alpha 1, skeletal muscle | motor activity (GO:0003774);muscle contraction (GO:0006936);muscle development (GO:0007517);structural constituent of cytoskeleton (GO:0005200) |
-10.27 | MYH7 | myosin, heavy polypeptide 7, cardiac muscle, beta | ATP binding (GO:0005524);actin binding (GO:0003779);calmodulin binding (GO:0005516);microfilament motor activity (GO:0000146);motor activity (GO:0003774);muscle contraction (GO:0006936);muscle development (GO:0007517);protein amino acid alkylation (GO:0008213);striated muscle contraction (GO:0006941);structural constituent of muscle (GO:0008307) |
-10.01 | TPM1 | tropomyosin 1 (alpha) | actin binding (GO:0003779);muscle development (GO:0007517);regulation of heart rate (GO:0008016);structural constituent of cytoskeleton (GO:0005200);structural constituent of muscle (GO:0008307) |
-9.10 | MYL1 | myosin, light polypeptide 1, alkali; skeletal, fast | calcium ion binding (GO:0005509);muscle development (GO:0007517);structural constituent of muscle (GO:0008307) |
-9.10 | TNNC1 | troponin C, slow | calcium ion binding (GO:0005509);muscle development (GO:0007517) |
-8.92 | PPP1R1A | protein phosphatase 1, regulatory (inhibitor) subunit 1A | glycogen metabolism (GO:0005977);protein phosphatase inhibitor activity (GO:0004864);signal transduction (GO:0007165);type 1 serine/threonine specific protein phosphatase inhibitor activity (GO:0004865) |
-8.79 | TNNC2 | troponin C2, fast | calcium ion binding (GO:0005509);muscle development (GO:0007517) |
-8.71 | TNNT1 | troponin T1, skeletal, slow | muscle development (GO:0007517);tropomyosin binding (GO:0005523) |
-8.70 | KRT14 | keratin 14 (epidermolysis bullosa simplex, Dowling-Meara, Koebner) | biological_process unknown (GO:0000004);structural constituent of cytoskeleton (GO:0005200);structural constituent of epidermis (GO:0030280) |
-8.67 | TTID | titin immunoglobulin domain protein (myotilin) | muscle contraction (GO:0006936);protein binding- (GO:0005515);structural constituent of muscle (GO:0008307) |
-8.49 | HUMMLC2B | myosin light chain 2 | calcium ion binding (GO:0005509);structural constituent of muscle (GO:0008307) |
-8.35 | TRIM | T-cell receptor interacting molecule | DNA binding (GO:0003677);cellular defense response (GO:0006968);signal transduction (GO:0007165);transmembrane receptor protein tyrosine kinase adaptor protein activity (GO:0005068) |
-8.20 | TTN | titin | ATP binding (GO:0005524);calmodulin binding (GO:0005516);cation transporter activity (GO:0008324);hematopoietin/interferon-class (D200-domain) cytokine receptor activity (GO:0004896);muscle development (GO:0007517);myosin binding (GO:0017022);protein amino acid phosphorylation (GO:0006468);protein serine/threonine kinase activity (GO:0004674);regulation of actin filament length (GO:0030832);somatic muscle development (GO:0007525);striated muscle contraction (GO:0006941);structural constituent of muscle (GO:0008307);structural molecule activity (GO:0005198);transferase activity (GO:0016740) |
-7.91 | CSRP3 | cysteine and glycine-rich protein 3 (cardiac LIM protein) | None |
-7.66 | MB | myoglobin | electron transporter activity (GO:0005489);globin (GO:0001524);oxygen transport (GO:0015671);oxygen transporter activity (GO:0005344);transport (GO:0006810) |
-7.46 | ENO3 | enolase 3, (beta, muscle) | glycolysis (GO:0006096);lyase activity (GO:0016829);magnesium ion binding (GO:0000287);phosphopyruvate hydratase activity (GO:0004634) |
-7.32 | NTRK2 | neurotrophic tyrosine kinase, receptor, type 2 | ATP binding (GO:0005524);kinase activity (GO:0016301);neurogenesis (GO:0007399);neurotrophin TRKB receptor activity (GO:0005015);neurotrophin binding (GO:0043121);protein amino acid phosphorylation (GO:0006468);receptor activity (GO:0004872);transferase activity (GO:0016740);transmembrane receptor protein tyrosine kinase activity (GO:0004714);transmembrane receptor protein tyrosine kinase signaling pathway (GO:0007169) |
-7.28 | MYL2 | myosin, light polypeptide 2, regulatory, cardiac, slow | calcium ion binding (GO:0005509);muscle development (GO:0007517);structural constituent of muscle (GO:0008307) |
-7.27 | TF | Transferring | ferric iron binding (GO:0008199);iron ion binding (GO:0005506);iron ion homeostasis (GO:0006879);iron ion transport (GO:0006826);transport (GO:0006810) |
-7.16 | ACSL1 | acyl-CoA synthetase long-chain family member 1 | digestion (GO:0007586);fatty acid metabolism (GO:0006631);ligase activity (GO:0016874);long-chain-fatty-acid-CoA ligase activity (GO:0004467);magnesium ion binding (GO:0000287);metabolism (GO:0008152) |
-7.10 | MYBPC1 | myosin binding protein C, slow type | actin binding (GO:0003779);cell adhesion (GO:0007155);cell adhesion molecule activity (GO:0005194);muscle development (GO:0007517);protein binding (GO:0005515);striated muscle contraction (GO:0006941);structural constituent of muscle (GO:0008307) |
-7.07 | S100A2 | S100 calcium binding protein A2 | biological_process unknown (GO:0000004);calcium ion binding (GO:0005509) |
-7.07 | PYGM | phosphorylase, glycogen; muscle (McArdle syndrome, glycogen storage disease type V) | amino acid metabolism (GO:0006520);carbohydrate metabolism (GO:0005975);glycogen metabolism (GO:0005977);glycogen phosphorylase activity (GO:0008184);transferase activity, transferring glycosyl groups (GO:0016757) |
-6.99 | ACTN2 | actinin, alpha 2 | actin binding (GO:0003779);calcium ion binding (GO:0005509);protein binding (GO:0005515);structural constituent of muscle (GO:0008307) |
-6.76 | MYBPC2 | myosin binding protein C, fast type | actin binding (GO:0003779);cell adhesion (GO:0007155);cell adhesion molecule activity (GO:0005194);muscle development (GO:0007517);protein binding (GO:0005515);striated muscle contraction (GO:0006941);structural constituent of muscle (GO:0008307) |
-6.71 | UCP2 | uncoupling protein 2 (mitochondrial, proton carrier) | binding (GO:0005488);mitochondrial transport (GO:0006839);proton transport (GO:0015992);small molecule transport (GO:0006832);transport (GO:0006810);transporter activity (GO:0005215);uncoupling protein activity (GO:0015302) |
-6.63 | NEB | nebulin | actin binding (GO:0003779);muscle development (GO:0007517);regulation of actin filament length (GO:0030832);somatic muscle development (GO:0007525);structural constituent of muscle (GO:0008307) |
-6.60 | IDH2 | isocitrate dehydrogenase 2 (NADP+), mitochondrial | carbohydrate metabolism (GO:0005975);glyoxylate cycle (GO:0006097);isocitrate dehydrogenase (NADP+) activity (GO:0004450);main pathways of carbohydrate metabolism (GO:0006092);metabolism (GO:0008152);oxidoreductase activity (GO:0016491);tricarboxylic acid cycle (GO:0006099) |
-6.47 | CSTA | cystatin A (stefin A) | cysteine protease inhibitor activity (GO:0004869);endopeptidase inhibitor activity (GO:0004866) |
-6.45 | MYH2 | myosin, heavy polypeptide 2, skeletal muscle, adult | ATP binding (GO:0005524);actin binding (GO:0003779);calmodulin binding (GO:0005516);microfilament motor activity (GO:0000146);motor activity (GO:0003774);muscle contraction (GO:0006936);muscle development (GO:0007517);muscle motor activity (GO:0003776);protein amino acid alkylation (GO:0008213);striated muscle contraction (GO:0006941) |
-6.42 | KRT4 | keratin 4 | cytoskeleton organization and biogenesis (GO:0007010);structural constituent of cytoskeleton (GO:0005200);structural molecule activity (GO:0005198) |
-6.40 | CLIC6 | chloride intracellular channel 6 | chloride transport (GO:0006821);ion transport (GO:0006811);voltage-gated chloride channel activity (GO:0005247) |
-6.27 | SPRR1A | small proline-rich protein 1A | structural molecule activity (GO:0005198) |
-6.25 | TNNI2 | troponin I, skeletal, fast | actin binding (GO:0003779);muscle development (GO:0007517) |
-6.22 | TNNI1 | troponin I, skeletal, slow | actin binding (GO:0003779);muscle development (GO:0007517);tropomyosin binding (GO:0005523) |
-6.17 | LDB3 | LIM domain binding 3 | electron transport (GO:0006118);electron transporter activity (GO:0005489);protein binding (GO:0005515) |
-6.14 | CRYAB | crystallin, alpha B | chaperone activity (GO:0003754);muscle contraction (GO:0006936);protein folding (GO:0006457);structural constituent of eye lens (GO:0005212);visual perception (GO:0007601) |
-6.12 | HFL1 | H factor (complement)-like 1 | plasma protein (GO:0005209) |
-6.15 | S100A1 | S100 calcium binding protein A1 | calcium ion binding (GO:0005509);cell communication (GO:0007154);intracellular signaling cascade (GO:0007242);neurogenesis (GO:0007399);protein binding (GO:0005515);zinc ion binding (GO:0008270) |
-6.09 | HSPB8 | heat shock 22 kDa protein 8 | biological_process unknown (GO:0000004);heat shock protein activity (GO:0003773);protein serine/threonine kinase activity (GO:0004674);transferase activity (GO:0016740) |
-5.93 | PPFIBP2 | PTPRF interacting protein, binding protein 2 (liprin beta 2) | None |
-5.88 | GHR | growth hormone receptor | endocytosis (GO:0006897);growth hormone receptor activity (GO:0004903);growth pattern (GO:0007150);receptor activity (GO:0004872);skeletal development (GO:0001501) |
-5.85 | ACSL1 | acyl-CoA synthetase long-chain family member 1 | digestion (GO:0007586);fatty acid metabolism (GO:0006631);ligase activity (GO:0016874);long-chain-fatty-acid-CoA ligase activity (GO:0004467);magnesium ion binding (GO:0000287);metabolism (GO:0008152) |
-5.84 | MGC42493 | hypothetical protein MGC42493 | nucleic acid binding (GO:0003676);zinc ion binding (GO:0008270) |
-5.73 | SCD | stearoyl-CoA desaturase (delta-9-desaturase) | fatty acid biosynthesis (GO:0006633);iron ion binding (GO:0005506);oxidoreductase activity (GO:0016491);stearoyl-CoA 9-desaturase activity (GO:0004768) |
-5.67 | hIAN2 | human immune associated nucleotide 2 | GTP binding (GO:0005525) |
-5.65 | PDE4DIP | phosphodiesterase 4D interacting protein (myomegalin) | None |
-5.63 | HBA2 | hemoglobin, alpha 2 | oxygen transport (GO:0015671);oxygen transporter activity (GO:0005344);protein binding (GO:0005515);transport (GO:0006810) |