Table 2 List of genes present in parental left ventricles (LVs) but absent in LV biopsies after microarray analysis. The Pathways (MAPPs) with the highest z-scores in MAPPFinder are given in column one with the related genes in those pathways which disappeared after amplification. Column two gives the Affymetrix Probe IDs of the corresponding genes. In column three the number of LV biopsies in which the gene is absent is given. (Three biopsies were used in the experiment so the maximum number is 3).
From: Biologically relevant effects of mRNA amplification on gene expression profiles
| Pathway/ Gene | Probe ID | # Biopsies (max = 3) |
|---|---|---|
| Glycogen Metabolism (12 genes on array; 8 genes changed; 67 %) | ||
| Phosphorylase B kinase alpha, muscle | 1369357_at | 3 |
| Phosphorylase B kinase gamma, muscle | 1387445_at | 3 |
| Phosphorylase B kinase gamma, testis/liver | 1367788_at | 3 |
| PP2A, catalytic beta | 1387261_at | 3 |
| PP2A, B subunit, R5 epsilon | 1387485_a_at | 2 |
| Glycogen phosphorylase, muscle | 1370982_at | 1 |
| Phosphoglucomutase | 1369473_at | 2 |
| Glycogen Synthase Kinase 3 beta | 1370267_at | 1 |
| Signal transduction of S1P receptor (17 genes on array; 5 genes changed; 29 %) | ||
| AKT2 | 1368832_at | 3 |
| G alpha i 1 | 1387505_at | 3 |
| G alpha i 2 | 1367844_at | 1 |
| ERK-1 | 1387771_a_at | 3 |
| ERK-2 | 1369078_at | 3 |
| G protein signaling pathways (50 genes on array; 17 genes changed; 34 %) | ||
| G beta 2 | 1398863_at | 3 |
| G beta T2 | 1398863_at | 3 |
| G gamma 3 | 1373202_at | 3 |
| G gamma 5 | 1398818_at | 2 |
| AC2 | 1367978_at | 1 |
| AC4 | 1368370_at | 2 |
| AC5 | 1368298_at | 3 |
| G alpha o 1 | 1368879_a_at | 2 |
| G alpha i 1 | 1387505_at | 3 |
| G alpha i 2 | 1367844_at | 1 |
| PKA 2 alpha reg | 1371059_at | 3 |
| G alpha 11 | 1387822_at | 2 |
| Phosphatase 2B Catalytic beta | 1387261_at | 3 |
| PKC gamma | 1369089_at | 1 |
| PKC eta | 1369830_at | 3 |
| G alpha 12 | 1369278_at | 2 |
| P115 RhoGEF | 1370002_at | 3 |
| TGF Beta Signaling Pathway (40 genes on array; 13 genes changed; 30 %) | ||
| Betaglycan | 1369219_at | 3 |
| TbR-I | 1369504_at | 3 |
| Activin | 1369012_at | 2 |
| BMP | 1387232_at | 1 |
| Smad1 | 1369174_at | 3 |
| Smad5 | 1369276_at | 3 |
| Smad7 | 1368896_at | 2 |
| Smad2 | 1368214_at | 1 |
| ERK1 | 1387771_a_at | 3 |
| NF-Kappa-B | 1370968_at | 1 |
| JNK2 | 1368646_at | 1 |
| Osteopontin | 1367581_a_at | 3 |
| SIP1 | 1368229_at | 1 |