Skip to main content

Table 4 Association of each NBS1 tSNP with breast cancer status and age-at-diagnosis of breast cancer

From: PedGenie: an analysis approach for genetic association testing in extended pedigrees and genealogies of arbitrary size

a. Case-Control cohort

  

rs12680687

rs709816

Weight

Statistic

Statistic (Empirical 95% CI)

p

Statistic (Empirical 95% CI)

p

Dominant

Chi-Square1

1.42

0.26

6.35

0.015

 

Odds Ratio1

1.25 (0.85, 1.83)

0.25

1.61 (1.10, 2.35)

0.019

 

Difference in Means2

0.68

0.51

-0.11

0.91

Recessive

Chi-Square1

2.48

0.13

0.076

0.78

 

Odds Ratio1

0.56 (0.24, 1.31)

0.18

0.93 (0.51, 1.68)

0.78

 

Difference in Means2

-0.57

0.60

-0.47

0.62

Additive

Chi-Square Trend1

0.086

0.80

2.73

0.10

 

Odds Ratio

    
 

HET vs. WT1

1.43 (0.95, 2.16)

0.079

1.77 (1.16, 2.72)

0.006

 

HOM vs. WT1

0.64 (0.27, 1.49)

0.31

1.22 (0.68, 2.19)

0.53

 

Means

    
 

HET vs. WT2

0.80

0.44

0.037

0.97

 

HOM vs. WT2

-0.34

0.74

-0.42

0.66

 

ANOVA2

0.41

0.68

0.10

0.91

Allele tests

Chi-Square1

0.09

0.79

2.99

0.084

 

Odds Ratio1

1.047 (0.77, 1.42)

0.78

1.27 (0.97, 1.67)

0.088

 

Means2

-8.19

0.31

-4.05

0.61

b. Nuclear Family cohort

  

rs12680687

rs709816

  

Statistic

p

Statistic

p

 

Trio TDT1

0.15

0.72

0.04

0.83

 

Sib TDT1

1.52

0.095

0.45

0.58

 

Combined TDT1

-1.20

0.23

-0.41

0.70

 

Trio QTDT2

-3

-

-3

-

 

Combined QTDT2

0.92

0.37

0.69

0.51

  1. 1Breast cancer status was used as the dependent variable
  2. 2Age-at-diagnosis was used as the dependent variable
  3. 3The Trio QTDT requires a minimum of 30 trio sets that contain at least one heterozygous parent, complete genotype data on the parents, and age-at-diagnosis of the affected offspring. We had only 25 probands that met all of these criteria; hence the test could not be run.
Back to article page

BMC Bioinformatics

ISSN: 1471-2105

Contact us