Figure 7

LD between the INS VNTR and the TH 01 microsatellite. Each TH 01 allele associates with a size range of VNTR alleles (256 and 263 associate with the class III alleles). This infers a greater rate of mutation in the VNTR because there is a wider range of allele sizes in the VNTR dimension significantly associated with TH 01 alleles than vice versa. Close-ups of individual allele plots are shown to indicate the magnitude of effect – black rectangle indicates expected haplotype frequency under no LD, coloured rectangle indicates the estimated haplotype frequency.