Figure 1

IDR and discovered genes versus t FDR for the two-study simulation data. a) Integration-driven discovery rate (IDR) versus threshold values of posterior probabilities of differential expression, γ, for the two-study simulated data and percent of differentially expressed genes p = 5% (blue checks), 10% (black diamonds), 25% (red triangles); b) The maximum number of differentially expressed genes versus true false discovery rate (t FDR) for individual analyses of Study 1 (red triangles), Study 2 (blue checks) and pooled analysis (black diamonds), for two-study simulated data and percent of differentially expressed genes p = 10%.