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Table 1 Agreement levels (%) and un-weighted kappa values by measured parameter for each comparison of TMA reviews.

From: The development and validation of the Virtual Tissue Matrix, a software application that facilitates the review of tissue microarrays on line

Parameters

Virtual vs. Glass

User A vs. B Virtual

User A vs. B Glass

 

% Agree

Kappa

% Agree

Kappa

% Agree

Kappa

% Core Present

71.3

0.507

67.1

0.414

67.4

0.448

% Tumour Present

47.3

0.407

37.9

0.283

33.0

0.244

% Membrane Staining

81.2

0.577

78.2

0.553

78.6

0.520

% Cytoplasmic Staining

64.0

0.37 3

42.8

0.198

65.9

0.280

% Nuclear Staining

85.0

0.226

84.9

0.524

95.8

0.239

Membrane Intensity

32.4

0.167

25.3

0.153

77.1

0.447

Cytoplasmic Intensity

58.2

0.306

50.8

0.263

65.2

0.234

Nuclear Intensity

82.1

0.109

83.3

0.474

89.2

0.234

  1. Virtual vs. Glass was the average of two users' agreements when comparing virtual with glass TMA reviews. User A vs. B Virtual was User A virtual TMA review compared with User B virtual TMA review. User A vs. B Glass was User A glass TMA review compared with User B glass TMA review.