Figure 2

Results of the gradient subtraction step (2dLoess) on a breast cancer array. Correction of the spatial gradient of a breast cancer array: continuous spatial gradients are correctly taken into account by the proposed normalization method. 1(a) Median-centered log-ratios; 1(b) spatial trend; 1(c) genomic profile without spatial normalization; 2(a) corrected log-ratios; 2(b) spatial trend after correction (the color scale is not the same as in 1(b)); 2(c) genomic profile after spatial normalization. The vertical gray dashed lines indicate the separation between chromosomes.