Variance filtering of spikes and target probesets. The distribution of correlation for data generated as in Figure 5, but grouped according to variance. Green – high variance probeset plus high variance spiking, blue – high variance probeset plus low variance spiking, magenta – low variance probeset plus low variance spiking, cyan – low variance probeset plus high variance spiking. Red – correlation before spiking. The effects of multiple targeting on correlation is most pronounced when the intended target is of low variance, however even in the case of high variance targets, correlation is likely to be influenced.