Halobacterium bicluster network as visualized using Cytoscape . Biclusters are represented as rectangular nodes, colored based upon significant functional annotations . Different colored edges represent different measures of cluster similarity or connectivity in various association networks (dark blue: KEGG  metabolic pathways; dark red: GO  functional similarity; light blue: motif similarity; yellow: operon membership; light red: COG  functional similarity; green: gene membership). Highly-connected (and therefore functionally-related) biclusters are placed near each other in the layout. The selected (grey) bicluster group near the bottom contains bacteriorhodopsin-associated biclusters, including the one in Fig. 1. Note that these biclusters have not been filtered to remove redundancy.