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Figure 6 | BMC Bioinformatics

Figure 6

From: High throughput profile-profile based fold recognition for the entire human proteome

Figure 6

A confident model of a previously unannotated domain built from a newly available template. Model built from novel template with the PDB code 2ane region 292–393 of the human protein sequence ENSG00000170500 with p < 0.001. At the time of writing this structure has no assigned SCOP [20] or CATH [21] code and only has a close DALI alignment to one other structure (1zbo). Prior to the week that the fold library was created for the experiment, no structural assignment could have been made to this region with that level of confidence. The template (2ane), along with 14 others with low sequence homology to known folds, was deposited into the PDB during the week that the fold library was created. During the experiment these new templates were assigned to 211 protein sequences from Homo sapiens, 23 of which were found to be significant (p < 0.05).

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