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Table 2 GO analyses of genes assigned to ICA components and to QTC clusters in the AML data set.

From: Independent component analysis reveals new and biologically significant structures in micro array data

  All genes in component Genes with positive loading Genes with negative loading
Gene cluster GO category ES1 GO category ES GO category ES
C3 extracellular 1.52 × 10-2     
  defenes resposne 4.18 × 10-2    defenes resposne 4.70 × 10-3
C6 antigen processing/exogeneous antigen 3.36 × 10-8    antigen processing/exogeneous antigen 2.30 × 10-9
C8 nucleosome assembly 4.39 × 10 -16 nucleosome assembly 1.36 × 10-17   
C13 inflammatory respons 1.6 × 10-3    inflammatory respons 5.12 × 10-5
C14    inflammatory respons 4.55 × 10-2   
C16 T-cell receptor complex 2.07 × 10-5 T-cell receptor complex 5.4 × 10-6   
C17 mitotic cell cycle 2.50 × 10-29 cell communication 2.76 × 10-2 mitotic cell cycle 1.41 × 10-32
C24      defense respons 7.59 × 10-6
C33      defense respons 1.57 × 10-2
C42    extracellular 4.08 × 10-2   
C44      respons to wounding 1.68 × 10-2
C45 immune response 6.75 × 10-7    immune response 6.44 × 10-9
C49      Cell-cell adhesion 3.23 × 10-2
C51      defense respons 2.14 × 10-2
C52 cell-cell signalling 2.85 × 10-2     
QTC1 immune response 5.5 × 10-9     
QTC2 extracellular 9.9 × 10-4     
QTC3 intracellullar 1.6 × 10-2     
QTC4 mitotic cell cycle 4.3 × 10-28     
QTC8 nucleus 9.7 × 10-3     
QTC14 unlocalized 3.4 × 10-2     
QTC23 organell organization and biogenesis 1.8 × 10-2     
  1. 1ES; Step down Bonferroni corrected Ease scores