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Table 2 GO analyses of genes assigned to ICA components and to QTC clusters in the AML data set.

From: Independent component analysis reveals new and biologically significant structures in micro array data

 

All genes in component

Genes with positive loading

Genes with negative loading

Gene cluster

GO category

ES1

GO category

ES

GO category

ES

C3

extracellular

1.52 × 10-2

    
 

defenes resposne

4.18 × 10-2

  

defenes resposne

4.70 × 10-3

C6

antigen processing/exogeneous antigen

3.36 × 10-8

  

antigen processing/exogeneous antigen

2.30 × 10-9

C8

nucleosome assembly

4.39 × 10 -16

nucleosome assembly

1.36 × 10-17

  

C13

inflammatory respons

1.6 × 10-3

  

inflammatory respons

5.12 × 10-5

C14

  

inflammatory respons

4.55 × 10-2

  

C16

T-cell receptor complex

2.07 × 10-5

T-cell receptor complex

5.4 × 10-6

  

C17

mitotic cell cycle

2.50 × 10-29

cell communication

2.76 × 10-2

mitotic cell cycle

1.41 × 10-32

C24

    

defense respons

7.59 × 10-6

C33

    

defense respons

1.57 × 10-2

C42

  

extracellular

4.08 × 10-2

  

C44

    

respons to wounding

1.68 × 10-2

C45

immune response

6.75 × 10-7

  

immune response

6.44 × 10-9

C49

    

Cell-cell adhesion

3.23 × 10-2

C51

    

defense respons

2.14 × 10-2

C52

cell-cell signalling

2.85 × 10-2

    

QTC1

immune response

5.5 × 10-9

    

QTC2

extracellular

9.9 × 10-4

    

QTC3

intracellullar

1.6 × 10-2

    

QTC4

mitotic cell cycle

4.3 × 10-28

    

QTC8

nucleus

9.7 × 10-3

    

QTC14

unlocalized

3.4 × 10-2

    

QTC23

organell organization and biogenesis

1.8 × 10-2

    
  1. 1ES; Step down Bonferroni corrected Ease scores