Table 4 GO analyses of genes assigned to ICA components and to QTC clusters in the HNSCC data set.
All genes in component | Genes with positive loading | Genes with negative loading | ||||
|---|---|---|---|---|---|---|
Gene cluster | GO category | ES1 | GO category | ES | GO category | ES |
C1 | muscle fiber | 6.0 10-14 | muscle fiber | 1.1 10-16 | ||
C4 | cell communication | 3.8 10-3 | cell communication | 1.0 10-2 | ||
C6 | immune response | 5.7 10-32 | defense response | 4.1 10-39 | ||
C7 | xenobiotic metabolism | 9.7 10-5 | xenobiotic metabolism | 9.2 10-5 | ||
C8 | extracellular | 2.8 10-2 | ||||
C9 | extracellular matrix | 2.3 10-28 | extracellular | 2.4 10-2 | extracellular matrix | 6.5 10-31 |
C12 | extracellular | 4.8 10-2 | ||||
C13 | extracellular | 1.1 10-2 | ||||
C15 | extracellular | 6.0 10-4 | ||||
C17 | membrane | 2.5 10-2 | membrane | 4.3 10-3 | ||
C18 | extracellular | 4.9 10-2 | extracellular | 4.7 10-3 | ||
C20 | morphogenesis | 1.5 10-2 | morphogenesis | 1.1 10-2 | ||
C26 | extracellular | 8.9 10-3 | ||||
C29 | extracellular | 4.5 10-5 | extracellular | 2.9 10-5 | ||
C30 | defense response | 5.8 10-17 | extracellular | 3.4 10-2 | defense response | 5.8 10-17 |
C33 | ectoderm development | 5.7 10-6 | ectoderm development | 1.74 10-6 | ||
C34 | response to biotic stimulus | 3.6 10-3 | response to biotic stimulus | 2.83 10-2 | ||
C35 | extracellular | 3.3 10-5 | extracellular | 1.9 10-3 | epidermal differentiation | 2.83 10-3 |
QTC3 | defense respons | 5 × 10-7 | ||||
QTC4 | ribonucleoprotein complex/ribosome | 2.5 × 10-8/5.1 × 10-6 | ||||
QTC5 | extracellular | 1.8 × 10-9 | ||||
QTC8 | defense respons/immune respons | 1.1 × 10-14/3.9 × 10-14 | ||||
QTC9 | muscle fiber | 7.5 × 10-21 | ||||
QTC10 | mitotic cell cycle | 9.6 × 10-8 | ||||
QTC13 | mitochondrion | 4.7 × 10-8 | ||||