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Table 4 GO analyses of genes assigned to ICA components and to QTC clusters in the HNSCC data set.

From: Independent component analysis reveals new and biologically significant structures in micro array data

  All genes in component Genes with positive loading Genes with negative loading
Gene cluster GO category ES1 GO category ES GO category ES
C1 muscle fiber 6.0 10-14 muscle fiber 1.1 10-16   
C4 cell communication 3.8 10-3    cell communication 1.0 10-2
C6 immune response 5.7 10-32    defense response 4.1 10-39
C7 xenobiotic metabolism 9.7 10-5 xenobiotic metabolism 9.2 10-5   
C8 extracellular 2.8 10-2     
C9 extracellular matrix 2.3 10-28 extracellular 2.4 10-2 extracellular matrix 6.5 10-31
C12 extracellular 4.8 10-2     
C13 extracellular 1.1 10-2     
C15    extracellular 6.0 10-4   
C17 membrane 2.5 10-2    membrane 4.3 10-3
C18 extracellular 4.9 10-2 extracellular 4.7 10-3   
C20 morphogenesis 1.5 10-2    morphogenesis 1.1 10-2
C26 extracellular 8.9 10-3     
C29 extracellular 4.5 10-5 extracellular 2.9 10-5   
C30 defense response 5.8 10-17 extracellular 3.4 10-2 defense response 5.8 10-17
C33 ectoderm development 5.7 10-6    ectoderm development 1.74 10-6
C34 response to biotic stimulus 3.6 10-3    response to biotic stimulus 2.83 10-2
C35 extracellular 3.3 10-5 extracellular 1.9 10-3 epidermal differentiation 2.83 10-3
QTC3 defense respons 5 × 10-7     
QTC4 ribonucleoprotein complex/ribosome 2.5 × 10-8/5.1 × 10-6     
QTC5 extracellular 1.8 × 10-9     
QTC8 defense respons/immune respons 1.1 × 10-14/3.9 × 10-14     
QTC9 muscle fiber 7.5 × 10-21     
QTC10 mitotic cell cycle 9.6 × 10-8     
QTC13 mitochondrion 4.7 × 10-8     
  1. 1ES; Step down Bonferroni corrected Ease scores