Table 2 Print-tip lowess normalization. In two of the analyses (80.I.1 and 80.II.1, see Table 3), the percentage of DE-genes allowed to influence the lowess curve estimates was kept at five different levels; 0, 1,6, 11, and 40%. The latter was obtained when all DE-genes were included. For each analysis, the sensitivities at the 0.05, 0.1, and 0.5% FPRs were observed together with the reflected bias.
From: Evaluation of microarray data normalization procedures using spike-in experiments
DE-genes (%) | 80.I.1 | 80.II.1 | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
0 | 1 | 6 | 11 | 40 | 0 | 1 | 6 | 11 | 40 | |
Sensitivity (%) at 0.05% FPR | 68 | 68 | 68 | 68 | 47 | 41 | 41 | 41 | 36 | 31 |
Sensitivity (%) at 0.1% FPR | 78 | 78 | 78 | 78 | 60 | 54 | 54 | 51 | 48 | 37 |
Sensitivity (%) at 0.5% FPR | 85 | 86 | 86 | 86 | 70 | 81 | 81 | 81 | 82 | 69 |
Reflected bias | -0.8 | -0.8 | -0.8 | -0.8 | -0.9 | -0.2 | -0.2 | -0.2 | -0.2 | -0.4 |