Figure 4From: Taking U out, with two nucleases?Three-dimensional models of trypanosomal REX EEP domains built using EEP domains whose structures have been determined by X-ray crystallography. The upper panel shows ribbon diagrams for two experimentally determined structures: 1AKO is E. coli exonuclease III (Fig. 2, ExoIII_Ec_1AKO) and 1HD7 is H. sapiens APE1 (APE1_Hs_1HD7). The lower panel shows ribbon diagrams of the homology-built structures: T. brucei REX2 (REX2_Tbrucei), T. brucei REX1 (REX1_Tbrucei) and L. major REX1 (REX1_Lmajor). The four-layered α, β sandwich fold in each EEP domain is shown in the same orientation with the substrate binding surface at the top.Back to article page