Figure 1

Validation of expression profiles. The results shown were calculated from 2138 arrays of type MG-U74Av2 (12 K). Similar results can be obtained using arrays of type Mouse430 2.0 (40 K) for categories available in both array types. For each gene, the signal intensity value indicated in each category is the average signal intensity value (of the corresponding probe set) from all arrays within this category. Average signal intensity values are available throughout all shown categories for all probe sets represented on the 12 K array. A. Anatomy expression profiles of genes shown in the literature to be preferentially expressed in muscle and heart (Mm.234274) or in retina (Mm.2965, Mm.39200, Mm.8008, Mm.20422). B1-B3. Development expression profiles of three genes previously shown to be expressed in oocytes and up to the 8-cell stage (Mm.28010), between E7.5 and E8.5 (Mm.197), and in adult mouse but low in embryo or newborn mice (Mm.3485). Developmental stages are defined as pre-natal (given in Theiler stages (TS); a: TS-1 to 2, b: TS-3 to 5, c: TS-6 to 9, d: TS-10 to 13, e: TS-14 to 18, f: TS-19 to 23, g: TS-24 to 27) or post-natal (given in days after birth; h: 0–3, i: 4–15, j: 16–63, k: 64–255, l: > 256). C and D. Response of Sirt1 (Mm.351459) to a set of stimuli (C) and to genetic modifications (D). Only treatments or mutations inducing strong up or down regulation are shown. Effects described in the text are highlighted. These precompiled responses are log-ratios from the average signal intensity values of treatment versus control samples from a variety of experiments and tissues.