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Table 1 feature propagation criteria

From: MACSIMS : multiple alignment of complete sequences information management system

Feature type Description Data source Feature category Core block Coverage
DOMAIN Structural/functional domain Uniprot (predicted) Domain 40%
PFAM-A Pfam database domain Pfam (reliable) Domain 40%
PROSITE Prosite motif or domain pattern Prosite (predicted) Single residue
Domain
100%
40%
STRUCT Secondary structure element Uniprot/PDB (reliable) SSE 70%
MODRES Modified residue Uniprot (predicted) Single residue
>1 residue
100%
70%
SITE Active site Uniprot (predicted) Single residue
>1 residue
100%
70%
VARSPLIC Splicing variant Uniprot (not propagated) N/A N/A
VARIANT Residue variants or mutations Uniprot (not propagated) N/A N/A
BLOCK Conserved core block Calculated in MACSIMS N/A N/A
REGION Conserved region Calculated in MACSIMS N/A N/A
LOWCOMP Low complexity segment Calculated in MACSIMS N/A N/A
TRANSMEM Potential transmembrane helix Calculated in MACSIMS N/A N/A
COIL Potential coiled coil Calculated in MACSIMS N/A N/A
  1. The data source indicates the original database from which the feature type is retrieved (predicted indicates a feature type that may contain predicted/unreliable information; reliable indicates a feature type that is assumed to manually verified/reliable). The Feature category refers to the three categories used to determine the criteria for feature propagation. Core block coverage indicates the percentage of the feature that should be covered by core blocks for the feature to be propagated.