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Table 6 Most frequently selected genes for the BRN dataset.

From: Differential prioritization between relevance and redundancy in correlation-based feature selection techniques for multiclass gene expression data

Rank Annotation Remarks Group
1 TYR tyrosinase (oculocutaneous albinism IA) Identified as marker for skin tumor class in [12] M
2 FLJ20624 **hypothetical protein FLJ20624 Related to the gene PAK1, which is associated with pancreatic cancer [35] 1
3 DMXL1 Dmx-like 1 Function still unknown, although high level of conservation suggests important roles [36] 4
4 CLDN4 claudin 4 Identified as marker for ovarian, bladder, lung, and stomach tumor classes in [12] M
5 TACSTD1 tumor-associated calcium signal transducer 1 Identified as marker for stomach, pancreatic, lung, and breast cancer classes in [12] M
6 M6PR mannose-6-phosphate receptor (cation dependent) Defective function of M6PR leads to hepatocellular carcinoma [37] 1
7 PLG plasminogen Identified as marker for stomach cancer class in [12] M
8 SPINT2 serine protease inhibitor, Kunitz type, 2 Found to be under-expressed in epithelial ovarian cancer patients [38] 1
9 SORD sorbitol dehydrogenase Suppresses growth arrest induced by a p53 tumor mutant in fission yeast [39] 2
10 FGA fibrinogen, A alpha polypeptide Mutation of FGA found in breast cancer patients [40] 1
11 BCL6 B-cell CLL/lymphoma 6 (zinc finger protein 51) Deregulation of BCL6 found in diffuse large cell lymphoma [41] 1
12 APOH apolipoprotein H (beta-2-glycoprotein I) Identified as marker for liver cancer class in [12] M
13 PAX8 paired box gene 8 Verified as marker for ovarian cancer in [12], also identified as marker for renal and breast cancer classes in [12] M
14 APCS amyloid P component, serum Produces normal circulating plasma protein that is deposited on amyloid fibrils 4
15 S100A1 S100 calcium-binding protein A1 Identified as marker for breast, kidney, and ovary cancer classes in [12] M
16 AMD1 S-adenosylmethionine decarboxylase 1 Specifically up-regulated in B cell lymphoma [42] 1
17 FABP1 fatty acid binding protein 1, liver Identified as marker for pancreatic cancer class in [12] M
18 HLCS holocarboxylase synthetase (biotin- [proprionyl-Coenzyme A-carboxylase (ATP-hydrolysing)] ligase) The enzyme holocarboxylase synthetase plays a role in gene regulation (determining whether genes are turned on or off) 4
19 ITIH3 pre-alpha (globulin) inhibitor, H3 polypeptide Its product is predominantly transcribed in liver, and is involved in pathological conditions such as tumor invasion and metastasis [43] 2
20 KRT18 keratin 18 Identified as marker for CNS (central nervous system) and stomach cancer classes in [12] M
21 LGALS4 lectin, galactoside-binding, soluble, 4 (galectin 4) Verified as marker for pancreatic cancer in [12], also identified as marker for stomach, liver, kidney, and breast cancer classes in [12] M
22 HELO1 homolog of yeast long chain polyunsaturated fatty acid elongation enzyme 2 Highly expressed in adrenal gland and testis (tissue-specific), probably involved in encoding the major histocompatibility complex, essential to human immune response [44] 3
23 EST Unknown sequence 4
24 QKI homolog of mouse quaking QKI (KH domain RNA binding protein) Specifically expressed in the central nervous system (CNS) 3
25 NDP Norrie disease (pseudoglioma) Regulates neural cell proliferation and differentiation. Norrie disease (caused by mutation of NDP) is also accompanied by intraocular tumor [45] 3
  1. Top 25 genes ranked from the most frequently selected genes for the BRN dataset. Group M: identified as a marker or repressor of a specific tumor type in originating study. Group 1: identified as a marker or repressor of a specific tumor type in other studies. Group 2: known to either promote or inhibit tumor in general. Group 3: tissue-specific genes. Group 4: unknown sequences and genes with either still-unidentified function or general housekeeping roles.