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Table 1 Specificity of designed sequences.

From: A maximum likelihood framework for protein design

Potential Average Z-score ratio SDev Z-score ratio Ranking (median) Target fold in top 1% (A) Target fold in top 10% Average seq. identity Correlation between (A) and mean entropy/site
μ -0.12 0.18 2249 0.5% 4.8% 5.76 % -0.26
μ + α14ac -0.10 0.18 2090 0.4% 6.3% 6.65 % -0.04
μ + ε 0.13 0.16 816.8 10.7% 33.5% 6.69 % 0.23
μ + α14ac + ε 0.45 0.23 32.7 53.6% 77.5% 7.82 % 0.64
  1. Scores of a fold recognition experiment for designed sequences (see Methods). 1,200 sequences were sampled from p(s | c, θ) for each potential, and submitted to THREADER for fold recognition. Z-score ratio: Z-score of designed sequence/Z-score of native sequence in target fold.