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Figure 1 | BMC Bioinformatics

Figure 1

From: A methodology for global validation of microarray experiments

Figure 1

Simulation of fold-change (FC) validation. A scatter plot from one simulation iteration is shown in (A) where the selected genes are circled in orange (random-stratified), green (random) and blue (top-ranked). The regression lines are orange (random-stratified), green (random), blue (top-ranked), red (identity) and brown (full benchmark sample). (B) Pair-link plot which connects paired data points from (A); the tendency for the lines to cross illustrates regression toward the mean. Box plots of the benchmark and the various sampling methods for the 1000 simulations are shown for (C) slope, (D) y-intercept, (E) precision (Pearson r), (F) accuracy and (G) concordance correlation coefficient (CCC). The lines of the box plots are color matched as above.

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