Figure 2
From: Cluster analysis of protein array results via similarity of Gene Ontology annotation
Graph similarity scoring method. The induced GO graphs for two yeast proteins illustrate graph similarity scoring using the Bioconductor method simUI. (A) The GO terms GO:0045944 positive regulation of transcription from RNA polymerase II promoter and GO:0008654 phospholipid biosynthesis are assigned to INO4/YOL108C. (B) The GO term GO:0006355 regulation of transcription, DNA-dependent is assigned to RSC30/YHR056C. The graph similarity between these two proteins is calculated by dividing the number of terms that are found in both of the individual induced GO graphs for each protein (shared nodes in blue) by the number of unique terms in both graphs. The graph similarity equals 20 shared nodes/40 unique nodes = 0.5