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Table 1 Analysis of 4-component curve resolution results from Alpha-696 data. Cell-cycle related genes (as classified by Spellman [32]) from Alpha-full (6044 genes) that have a strong correlation (r>0.8) with extracted profiles are listed, along with the associated phase. The numbers in parentheses give the ranking in the correlation list and the correlation coefficient. See text for more details.

From: Multivariate curve resolution of time course microarray data

 

Curve 1

Curve 2

Curve 3

Curve 4

 

MFA1 G1 (1, 0.96)

SVS1 G1 (1, 0.98)

ALK1 M (2, 0.96)

ASH1 M/G1 (5, 0.94)

 

AGA2 M/G1 (5, 0.88)

POL30 G1 (2, 0.97)

HTA3 S (6, 0.94)

EGT2 M/G1 (6, 0.94)

 

TIP1 M/G1 (12, 0.85)

MNN1 G1 (3, 0.96)

CDC5 M (7, 0.94)

PCL9 M/G1 (8, 0.92)

 

GFA1 M/G1 (22, 0.82)

CLN2 G1 (4, 0.96)

CLB2 M (11, 0.93)

SIC1 M/G1 (9, 0.91)

 

GLK1 M/G1 (31, 0.81)

RNR1 G1 (5, 0.96)

BUD4 M (17, 0.93)

FAA3 M/G1 (14, 0.88)

  

CDC21 G1 (10, 0.94)

KIP2 G2 (21, 0.92)

CDC6 M/G1 (20, 0.85)

  

MCD1 G1 (11, 0.93)

ERG3 G2 (22, 0.92)

MCM3 M/G1 (24, 0.84)

  

CTF4 G1 (12, 0.93)

CLB1 M (24, 0.92)

MCM2 M (25, 0.83)

  

SMC3 G1 (13, 0.93)

ACE2 M (26, 0.92)

PHO11 M (26, 0.83)

  

MSH2 G1 (15, 0.93)

MOB1 M (27, 0.91)

BUD9 G1 (27, 0.83)

  

CDC9 G1 (16, 0.92)

AUR1 G2 (28, 0.91)

PHO12 M (33, 0.82)

  

MSH6 G1 (18, 0.92)

ORC1 G2 (32, 0.91)

CDC47 M (34, 0.82)

  

RFA2 G1 (19, 0.92)

TUB2 G2 (33, 0.91)

CDC46 M/G1 (35, 0.81)

  

RAD27 G1 (20, 0.92)

SSO2 G2 (35, 0.90)

FTR1 M (36, 0.81)

  

RAD51 G1 (21, 0.92)

CWP2 G2 (47, 0.90)

PHO5 M (38, 0.81)

  

CSI2 G1 (24, 0.91)

NUM1 G2 (62, 0.89)

 
  

RNR3 G1 (25, 0.91)

MYO1 M (65, 0.89)

 
  

RAD53 G1 (26, 0.91)

NUF2 M (73, 0.89)

 
  

RSR1 G1 (29, 0.90)

TEM1 M (80, 0.89)

 
  

RFA1 G1 (30, 0.90)

CWP1 G2 (84, 0.89)

 

Ntot (Nmatch) with r>0.8:

35 (5)

353 (92)

3395 (121)

43 (15)

Classification:

None

G1

S, G2, M

M/G1

Scores: G1

0.008

0.596

0.161

0.007

S

0.000

0.154

0.715

0.000

G2

0.000

0.000

0.696

0.000

M

0.000

0.000

0.539

0.081

M/G1

0.082

0.062

0.040

0.173