Figure 1

The proteins are mapped on a grid (A); In the common representation there is a differentiation between cells representing the surface (S) and the interior (I) (B), which results in the distribution of values as shown in C. Since each cell also represents the underlying amino acid (D), in the new representation (E) as it is used here each value is composed of an numerical value for surface and interior (S/I) and a weighting factor for each amino acid (W_AA).