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Table 1 Comparison of Proposed Method Performance against Existing Methods on Publicly Available Datasets. As shown in the table, the proposed method achieves a high classification performance on all datasets tested. In particular, the performance is superior to that of the referenced method in 3/6 datasets and matches that of the referenced method in the remaining 3 datasets. The last column shows the ratio of genes selected by both ours and the cross reference method over the total number of gene-features in the cross reference method. Abbreviations: S2N: Signal to Noise, CC: Correlation Coefficient, NA: Neighborhood Analysis, FA: Factor Analysis, 2-tail T: 2-Tail Student test, ER: Expression Ratio, K-NN: K-Nearest Neighbors. *Outlier samples for this dataset were omitted from the classification in both the reference and our method.

From: Individualized markers optimize class prediction of microarray data

Cross Reference Method

Our Method

Data Set

Performance

Selection/Classification

Performance

Sensitivity

Specificity

Common genes

 

CV

Test

 

CV

Test

   

AML/ALL

-

29/34

S2N/NA

-

33/34

90.9%

100%

48/50

Breast Cancer

47/49

5/5*

CC/FA

48/49

5/5*

100%*

100%*

81/100

Lung Cancer

-

148/149

2-tail T/ER

-

148/149

93.3%

100%

8/8

AML/MLL/ALL

54/57

14/15

CC/K-NN

56/5

4/4, 3/3, 8/8

-

-

14/45

CNS

47/60

-

S2N/K-NN

55/60

-

85.7%

94.9%

22/100

Lymph Node

31/34

-

CC/FA

31/34

-

83.3%

95.4%

N/A