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Table 2 Clustering of 75 attenuated Brucella genes found from literature search using the COG classification method.

From: BBP: Brucella genome annotation with literature mining and curation

COG clusters

Mutated Brucella genes

C: Energy production and conversion

4: cydB, eryB, narG, pyc

D: Cell cycle control, mitosis and meiosis

1: virB5

E: Amino acid transport and metabolism

15: aroC, aspC, gcvP, gcvT, glnA, glyA, hisC, hisD, hisF, leuA, leuC, lysA, pepN, pheA, serB

F: Nucleotide transport and metabolism

10: dut, purD, purE, purF, purH, purl, purM, purN, pyrB, pyrD

G: Carbohydrate transport and metabolism

7: eryC, gnd, ilvD, pgi, pgm, ugpA, zwf

H: Coenzyme transport and metabolism

3: cobB, hemH, ilvC

I: Lipid transport and metabolism

2: bacA, uppS

J: Translation

3: pth, rplS, rpsA

K: Transcription

3: miaA, oxyR, rpoA

L: Replication, recombination and repair

2: recA, xseA

M: Cell wall/membrane biogenesis

6: gmd, omp10, omp19, omp25, virB1, wboA

O: Posttranslational modification, protein turnover, chaperones

5: cydD, degP, dnaK, lon, tig

P: Inorganic ion transport and metabolism

2: sodC, znuA

Q: Secondary metabolites biosynthesis, transport and catabolism

1: pncA

R: General function prediction only

2: gltD, hfq

T: Signal transduction mechanisms

4: bvrR, bvrS, ntrC, ntrY

U: Intracellular trafficking and secretion

9: fliF, virB2, virB10, virB11, virB3, virB4, virB6, virB8, virB9

-: Not in COGs

6: cowB, glnD, gluP, gpt, norM, wbkB