Figure 3
From: MANET: tracing evolution of protein architecture in metabolic networks
Phylogenomic tree reconstruction of protein fold architecture generated from a domain census in 174 completely sequenced genomes. The structural census was defined by advanced HMMs and assigned domain structure to about 60% of genomic sequences. Three optimal trees of 115,818 steps were obtained after a heuristic search (CI = 0.134, RI = 0.696; RC = 0.093; g1 = -0.406; p < 0.01). The consensus phylogenomic tree is shown as a rooted dendrogram with terminals colored according to ranges of ancestry values (A), an unrooted hyperbolic tree (B), and a rooted circle tree (C). Terminal taxa are not labeled except for the fold of oldest origin, c.37, the P-loop hydrolase fold.