Box-and-whiskers plot describing global frequency distribution profiles. A. Comparison of ancestry values derived from structural models using the join operation (population group A) and predicted using HMMs (population group B) in metabolic MANET. B. Statistical analysis of ancestry distribution in metabolic mesonetworks. Mesonetwork distributions next to vertical bars headed by the same letter are not significantly different (p < 0.05). The Least Squares (LS) means and number of enzymes analyzed (n) are given for each mesonetwork. Skeletal boxes describe median, lower and upper quartiles, and whiskers describe maximum and minimum values. Crosses indicate mean values.